{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:12:26Z","timestamp":1770700346621,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":5768,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previously, we have shown that the intravenous (i.v.) injection of allogeneic lymphocytes across an H\u20102 class I\u2010mutant disparity leads to specific skin allograft tolerance caused by irradiation\u2010sensitive donor T cells, which function as veto cells. In the present study, we show that the i.v. injection of H\u20102 class II\u2010incompatible spleen cells also results in specific skin allograft tolerance. However, tolerance induction depends on the presence of irradiation\u2010resistant non\u2010T cells in the donor cell inoculum. Thus, different mechanisms operate in tolerance induction across an H\u20102 class I <jats:italic>vs<\/jats:italic>. H\u20102 class II mismatch. I.v. injection of allogeneic spleen cells across an H\u20102 class I plus class II disparity does not result in skin allograft tolerance. Finally, our data show that transfusion\u2010induced suppression of the delayed\u2010type hypersensitivity response against alloantigens does not correlate with skin allograft tolerance induced by i.v. injected allogeneic lymphocytes. In conclusion, the type of H\u20102 mismatch between transfusion donor and recipient not only determines the occurrence of allograft tolerance but also the mechanism leading to tolerization.<\/jats:p>","DOI":"10.1002\/eji.1830200232","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T11:48:34Z","timestamp":1172749714000},"page":"441-444","source":"Crossref","is-referenced-by-count":24,"title":["Induction of transplantation tolerance by intravenous injection of allogeneic lymphocytes across an H\u20102 class II mismatch. Different mechanisms operate in tolerization across an H\u20102 class I <i>vs<\/i>. H\u20102 class II disparity"],"prefix":"10.1002","volume":"20","author":[{"given":"Esther","family":"Van Twuyver","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Martin Kast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob J. D.","family":"Mooijaart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis J. M.","family":"Melief","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo P.","family":"De Waal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1903","author":"Cochrum K. C.","year":"1979","journal-title":"Transplant. Proc."},{"key":"e_1_2_1_3_2","first-page":"160","author":"Salvatierra O.","year":"1987","journal-title":"Transplant. 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