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For that purpose, spleen cells from a mercury\u2010injected rat were fused and the resulting hybridomas tested for their anti\u2010Id activity against monoclonal anti\u2010glomerular basement membrane (GBM) antibodies produced in this model. A monoclonal antibody (mAb) was obtained that specifically reacted in an enzyme\u2010linked immunosorbent assay with an anti\u2010GBM mAb and to a much lesser extent with another one produced in the same fusion. In Western blot experiments this autoanti\u2010Id mAb reacted under reducing conditions with the \u03c7 L chains but not with the H chains of the two anti\u2010GBM mAb. It did not react with the \u03c7 L chains of eight other rat mAb. This mAb is therefore an autoanti\u2010Id mAb that recognizes a V<jats:sub>x<\/jats:sub>\u2212associated Id expressed on two anti\u2010GBM mAb. These results demonstrate that anti\u2010GBM antibodies and their corresponding autoanti\u2010Id antibodies are simultaneously produced during this disease. Whether or not these autoanti\u2010Id antibodies have a regulatory and\/or a pathogenic role in this disease remains to be established.<\/jats:p>","DOI":"10.1002\/eji.1830200512","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T12:14:10Z","timestamp":1172751250000},"page":"1027-1031","source":"Crossref","is-referenced-by-count":8,"title":["A spontaneous hybridoma producing autoanti\u2010idiotypic antibodies that recognizea V<sub>x<\/sub>\u2212associated idiotope in mercury\u2010induced autoimmunity"],"prefix":"10.1002","volume":"20","author":[{"given":"Jean\u2010charles","family":"Gu\u00e9ry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Druet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1982.tb00949.x"},{"key":"e_1_2_1_3_2","first-page":"173","volume":"28","author":"Sapin C.","year":"1977","journal-title":"Clin. 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