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The latter cells were also cloned and did not display this suppressive activity, were CD4<jats:sup>+<\/jats:sup> and proliferated vigorously to <jats:italic>M. leprae<\/jats:italic> presented by autologous HLA\u2010DR molecules. We shall refer to these cells as T helper (T<jats:sub>h<\/jats:sub>) cells. Most of the suppressive T cell clones (T<jats:sub>s<\/jats:sub>) were also CD4<jats:sup>+<\/jats:sup> and also proliferated to <jats:italic>M. leprae<\/jats:italic> presented by HLA\u2010DR, but much less strongly than T<jats:sub>h<\/jats:sub> cells.<\/jats:p><jats:p>In this study we report on our search for (a) the mechanism of this apparently antigen\u2010specific suppression by T cells, and (b) a possible phenotypic difference between T<jats:sub>h<\/jats:sub> and T<jats:sub>s<\/jats:sub> clones. The two main conclusions are that T<jats:sub>s<\/jats:sub> clones possess a lytic machinery, but that <jats:italic>M. leprae<\/jats:italic>\u2010specific suppression and cytotoxicity can be clearly dissociated, and that the only phenotypic difference between T<jats:sub>h<\/jats:sub> and T<jats:sub>s<\/jats:sub> is the presence of the CD28 marker on T<jats:sub>h<\/jats:sub> and its absence on T<jats:sub>s<\/jats:sub> clones.<\/jats:p>","DOI":"10.1002\/eji.1830200613","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T12:08:28Z","timestamp":1172750908000},"page":"1281-1288","source":"Crossref","is-referenced-by-count":22,"title":["Human suppressor T cell clones lack CD28"],"prefix":"10.1002","volume":"20","author":[{"given":"Shu Guang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom H. 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