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L chain genes were found to be rearranged in these lines and to lead to transcripts with altered V regions. Although these abnormal transcripts displayed specific abnormalities in each cell line, they shared some features, including large deletions involving the V\u2010J junction. In one cell line, L chain transcripts made up of either V<jats:sub><jats:italic>x<\/jats:italic><\/jats:sub>I subgroup gene J<jats:sub><jats:italic>x<\/jats:italic><\/jats:sub>3 or V<jats:sub><jats:italic>x<\/jats:italic><\/jats:sub>IV gene\u2010J<jats:sub><jats:italic>x<\/jats:italic><\/jats:sub>4 recombination products bore a similar alteration: the donor splice site of the rearranged J<jats:sub><jats:italic>x<\/jats:italic><\/jats:sub> segment was modified, leading to the alternate use of the donor site of either the leader peptide exon or the next 3\u2032 unrearranged J<jats:sub><jats:italic>x<\/jats:italic><\/jats:sub> segment.<\/jats:p>","DOI":"10.1002\/eji.1830200906","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T03:25:28Z","timestamp":1172719528000},"page":"1905-1910","source":"Crossref","is-referenced-by-count":8,"title":["Immunoglobulin light chain transcripts with altered V regions in Burkitt's lymphoma cell lines producing short \u03bc chains"],"prefix":"10.1002","volume":"20","author":[{"given":"Michel","family":"Cogn\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Mounir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Aucouturier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Preud'homme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Nau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Guglielmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2494(89)90115-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9199"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830181003"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910430534"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4049\/jimmunol.144.1.342","volume":"144","author":"Mounir S.","year":"1990","journal-title":"J. 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