{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:45:08Z","timestamp":1762271108618},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":5556,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experimental autoimmune encephalomyelitis (EAE) is a T cell\u2010mediated autoimmune disease inducible in rodents by immunization of brain\u2010specific antigens such as myelin basic protein (MBP). It is also well known that various strains of rats differ in their susceptibility to EAE upon active immunization. To elucidate the immune mechanisms of susceptibility and resistance to EAE, we first examined the T cell repertoire for MBP using thymectomized chimeras that possessed thymuses from EAE\u2010susceptible (LEW) or EAE\u2010resistant (BM) strains. It was revealed that T cell specificity of these chimeras was skewed toward that of the grafted thymus. Very interestingly, the chimeras bearing thymuses from the resistant strain developed severe EAE, keeping a hole in the encephalitogenic 68\u201088 sequence of MBP. These findings suggest that the strain\u2010specific T cell repertoire itself is not involved in the regulation of EAE susceptibility. Furthermore, the analysis of the chimeras reconstituted with F<jats:sub>1<\/jats:sub> T cells and marrow cells from various strains indicates that the major histocompatibility complex (MHC) molecules expressed on accessory cells primarily determine susceptibility or resistance to EAE. We finally showed, using various inbred and congenic rats carrying RT1<jats:sup>l<\/jats:sup> or RT1<jats:sup>n<\/jats:sup>, that susceptibility to EAE of rats carrying RT1<jats:sup>l<\/jats:sup> is heavily influenced by the background genes, whereas resistance to EAE of rats carrying RT1<jats:sup>n<\/jats:sup> is primarily regulated by the MHC molecules expressed on accessory cells without influence of the background genes.<\/jats:p>","DOI":"10.1002\/eji.1830200934","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T03:25:28Z","timestamp":1172719528000},"page":"2119-2126","source":"Crossref","is-referenced-by-count":17,"title":["Analysis of the T cell repertoire for myelin basic protein in thymus\u2010grafted and other types of chimera: evidence that major histocompatibility complex molecules on accessory cells rather than T cell specificity mainly regulate susceptibility to autoimmune encephalomyelitis"],"prefix":"10.1002","volume":"20","author":[{"given":"Yoh","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"135","volume":"16","author":"Waksman B. H.","year":"1962","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(87)90055-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4049\/jimmunol.129.1.303","volume":"129","author":"Ben\u2010Nun A.","year":"1982","journal-title":"J. Immunol."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(86)90036-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(85)80026-6"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4049\/jimmunol.135.1.229","volume":"135","author":"Vandenbark A. A.","year":"1985","journal-title":"J. Immunol."},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4049\/jimmunol.136.2.511","volume":"136","author":"Beraud E.","year":"1986","journal-title":"J. Immunol."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.2.502"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.6.2107"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/324258a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.3.1181"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.4049\/jimmunol.139.4.1075","volume":"139","author":"Zamvil S. S.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90558-2"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90079-7"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.27"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830190210"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90174-6"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/00327487208061467"},{"key":"e_1_2_1_20_2","first-page":"23","volume":"65","author":"Matsumoto Y.","year":"1988","journal-title":"Immunology"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(87)90032-4"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4049\/jimmunol.135.1.80","volume":"135","author":"Sopori M. L.","year":"1985","journal-title":"J. Immunol."},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.3.766"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/319672a0"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830120710"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.4049\/jimmunol.136.10.3668","volume":"136","author":"Matsumoto Y.","year":"1986","journal-title":"J. Immunol."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(86)90033-0"},{"key":"e_1_2_1_28_2","first-page":"621","volume":"66","author":"Matsumoto Y.","year":"1989","journal-title":"Immunology"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(85)90270-9"},{"key":"e_1_2_1_30_2","first-page":"511","volume-title":"Experimental allergic encephalomyelitis: A useful model for multiple sclerosis","author":"Martenson R. E.","year":"1984"},{"key":"e_1_2_1_31_2","first-page":"215","volume":"69","author":"Matsumoto Y.","year":"1990","journal-title":"Immunology"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.4049\/jimmunol.126.4.1553","volume":"126","author":"Singer D. E.","year":"1981","journal-title":"J. Immunol."},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830110409"},{"key":"e_1_2_1_34_2","first-page":"151","volume-title":"Immunogenetics","author":"Paul W. E.","year":"1984"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.4049\/jimmunol.143.7.2083","volume":"143","author":"Davis C. B.","year":"1989","journal-title":"J. Immunol."},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.3.767"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.22.8608"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.5.1681"},{"key":"e_1_2_1_39_2","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.4049\/jimmunol.141.5.1489","volume":"141","author":"Happ M. P.","year":"1988","journal-title":"J. Immunol."},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.12.4771"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.2.431"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830200934","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830200934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T20:32:15Z","timestamp":1698006735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830200934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["10.1002\/eji.1830200934"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830200934","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}