{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T14:53:35Z","timestamp":1760799215553},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":5526,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The major histocompatibility complex (MHC) controls of the outcome of the immune response to T cell\u2010dependent antigens by dictating whether T cell responsiveness will result (MHC\u2010immune response [Ir] genes) or alternatively T cell nonresponsiveness will occur, possibly through the activation of suppressor cells (MHC\u2010immune suppression [Is] genes).<\/jats:p><jats:p>In mice, I\u2010A molecules typically restrict antigen\u2010specific helper T cells. In contrast, H\u20102 I\u2010E molecules have been reported to control nonresponsiveness to a variety of antigens through antigen\u2010specific suppressor cells. In analogy, HLA\u2010DR molecules are the dominant restriction elements for helper Tcells in man. This forces the question whether DQ molecules may be involved in controlling nonresponsiveness in man, <jats:italic>e.g.<\/jats:italic> through suppression. In one system, T cell nonresponsiveness to <jats:italic>Schistosoma japonicum<\/jats:italic>, evidence has been presented supporting this notion. We have now used a second system, <jats:italic>Mycobacterium leprae<\/jats:italic>\u2010specific T cell nonresponsiveness, that is typically found in lepromatous leprosy patients.<\/jats:p><jats:p>We find positive but limited evidence for a role for HLA\u2010DQ molecules in controlling Tcell nonresponsiveness to <jats:italic>M. leprae<\/jats:italic> of the 22 nonresponder patients tested, 4 showed a proliferative T cell response to <jats:italic>M. leprae<\/jats:italic> after the addition of DQ\u2010 but not DR\u2010specific mAb to the cell cultures. In one of the four BCG nonresponders, anti\u2010DQ mAb had a similar effect.<\/jats:p>","DOI":"10.1002\/eji.1830201027","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T11:34:39Z","timestamp":1172748879000},"page":"2347-2350","source":"Crossref","is-referenced-by-count":22,"title":["HLA\u2010DQ molecules and the control of <i>Mycobacterium leprae<\/i>\u2010specific T cell nonresponsiveness in lepromatous leprosy patients"],"prefix":"10.1002","volume":"20","author":[{"given":"Tom H. M.","family":"Ottenhoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Walford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. B. B.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Sasazuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.03.040185.001321"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(86)90127-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1983.tb00709.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1982.tb00695.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00563514"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830171125"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(87)90236-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/328432a0"},{"key":"e_1_2_1_10_2","first-page":"73","volume":"36","author":"Qvigstad E.","year":"1985","journal-title":"Prog. 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Lepr."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830201027","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830201027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:37:38Z","timestamp":1698043058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830201027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1990,10]]}},"alternative-id":["10.1002\/eji.1830201027"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830201027","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,10]]}}}