{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:02:30Z","timestamp":1791147750996,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T00:00:00Z","timestamp":1134518400000},"content-version":"vor","delay-in-days":5492,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two distinct non\u2010overlapping populations of TcR1<jats:sup>+<\/jats:sup> (\u03b3\/\u03b4) T cells have been described: the first, bearing the disulfide\u2010linked \u03b3\/\u03b4 heterodimer, is predominant in the peripheral blood; the second, expressing the non\u2010disulfide\u2010linked form of TcR1, is mostly confined to epithelial tissues (lung, gut, skin).TcR1<jats:sup>+<\/jats:sup> lymphocytes may be cytotoxic and could be involved in anti\u2010tumor immunity, especially against tumors at epithelial sites. Freshly derived tumor\u2010infiltrating lymphocytes (TIL) obtained from two patients with lung cancer were enriched in CD3<jats:sup>+<\/jats:sup>WT31<jats:sup>\u2212<\/jats:sup> cells. The percentage of this subset substantially increased upon culture in the presence of interleukin 2. These cells were TcR1<jats:sup>+<\/jats:sup> as demonstrated by immunofluorescence and immunoprecipitation. In one case only 40% of this population reacted with \u03b4TCS1 mAb, that recognizes the non\u2010disulfide\u2010linked form of TcR1, and co\u2010expressed the CD8 antigen. Cultured TcR1<jats:sup>+<\/jats:sup> TIL were able to kill fresh autologous tumor cells, K\u2010562 and, to a lesser extent, some natural killer\u2010resistant cell lines and allogeneic lung tumor cells in 4\u2010h <jats:sup>51<\/jats:sup>Cr\u2010release cytotoxicity assays. The fractionated \u03b4TCS1<jats:sup>+<\/jats:sup> TIL lysed only autologous tumor cells and K\u2010562, whereas the lytic activity against all the other targets was confined to the \u03b4TCS1<jats:sup>\u2212<\/jats:sup> subset. Moreover, the autotumor cytotoxicity was inhibited by anti\u2010HLA class I but not by anti\u2010CD1c or anti\u2010LFA\u20101 mAb, suggesting that killing of the autologous tumor cells and non\u2010major histocompatibility complex\u2010restricted cytotoxicity are mediated by different mechanisms.<\/jats:p>","DOI":"10.1002\/eji.1830201224","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T11:54:29Z","timestamp":1172750069000},"page":"2685-2689","source":"Crossref","is-referenced-by-count":76,"title":["Selective lysis of the autologous tumor by \u03b4TCS1<sup>+<\/sup> \u03b3\/\u03b4<sup>+<\/sup> tumor\u2010infiltrating lymphocytes from human lung carcinomas"],"prefix":"10.1002","volume":"20","author":[{"given":"M.","family":"Raffaella Zocchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Ferrarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Rugarli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910370602"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.4.1419"},{"key":"e_1_2_1_4_2","first-page":"173","volume":"47","author":"Rabinowich H.","year":"1987","journal-title":"Cancer Res."},{"key":"e_1_2_1_5_2","first-page":"206","volume":"48","author":"Belldegrun A.","year":"1988","journal-title":"Cancer Res."},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.4049\/jimmunol.142.10.3714","volume":"142","author":"Topalian S. 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