{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:54:02Z","timestamp":1773183242131,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T00:00:00Z","timestamp":1134518400000},"content-version":"vor","delay-in-days":5492,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alpha heavy chain diseases (HCD) are lymphoproliferative disorders characterized by the production of truncated \u03b1 immunoglobulin heavy chain without associated light chains, \u03b1 HCD MAL is featured by multiple structural alterations of the \u03b1<jats:sub>1<\/jats:sub> productive gene and on original t(9;14)(p11;q32) translocation involving the other rearranged \u03b1 allele. We present here the structure of the der(9) chromosome. Sequence analysis provides evidence that the translocation occurred after local pairing of the two chromosomes mediated by an almost perfect nonameric sequence, followed by a staggered double\u2010strand break of chromosome 14. This translocation occurred on a V(D)J rearranged locus; unexpectedly, there were a deletion of the 3' part of the V<jats:sub>H<\/jats:sub> gene, several insertions of non\u2010immunoglobulin\u2010related genes and multiple mutations, <jats:italic>i.e.<\/jats:italic> alterations reminiscent of those occurring on the HCD productive genes.<\/jats:p>","DOI":"10.1002\/eji.1830201230","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T11:54:29Z","timestamp":1172750069000},"page":"2731-2735","source":"Crossref","is-referenced-by-count":7,"title":["Alpha heavy chain disease of patient MAL: structure of the non\u2010functional rearranged \u03b1 gene translocated on chromosome 9"],"prefix":"10.1002","volume":"20","author":[{"given":"Pascale","family":"Pellet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Tsapis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Claude","family":"Brouet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.162.3860.1396"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0300-5089(21)00292-3","volume":"5","author":"Rambaud J. C.","year":"1976","journal-title":"Clin. Gastroenterol."},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.4049\/jimmunol.143.11.3821","volume":"143","author":"Tsapis A.","year":"1989","journal-title":"J. Immunol."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90158-5"},{"key":"e_1_2_1_6_2","first-page":"653","volume":"4","author":"Pellet P.","year":"1989","journal-title":"Oncogene"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-4754.1982.tb01001.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(75)80083-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.322279"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90400-1"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(83)90418-9"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(80)90196-5"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113722"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.10.3260"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90243-0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(85)90092-7"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90400-1"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb03309.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2494(89)90115-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.3.855"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.4049\/jimmunol.141.5.1738","volume":"141","author":"Cogn\u00e9 M.","year":"1988","journal-title":"J. Immunol."},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.4049\/jimmunol.139.5.1718","volume":"139","author":"Nottenburg C.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.4049\/jimmunol.141.5.1762","volume":"141","author":"Guglielmi P.","year":"1988","journal-title":"J. Immunol."},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.8.2689"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830191119"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/320549a0"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90666-0"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/324158a0"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/315340a0"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3874430"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04302.x"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.8.2396"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.8.2748"},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1002\/j.1460-2075.1988.tb03040.x","volume":"7","author":"Boehm T.","year":"1988","journal-title":"EMBO J."},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90148-9"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.13.5044"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(88)90066-1"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90429-8"},{"key":"e_1_2_1_39_2","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.4049\/jimmunol.141.10.3625","volume":"141","author":"Borzillo G. V.","year":"1988","journal-title":"J. Immunol."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830201230","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830201230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T14:57:00Z","timestamp":1697986620000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830201230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["10.1002\/eji.1830201230"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830201230","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}