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The present study demonstrates that the expression of the T44 Id is strongly associated with the recognition by anti\u2010TG autoantibodies of a specific epitopic cluster on human TG. The epitopic reactivity of anti\u2010TG autoantibodies was determined using a competitive inhibition assay with a panel of 15 monoclonal antibodies that define six antigenic clusters on TG. All T44<jats:sup>+<\/jats:sup> autoantibodies from patients recognized cluster II, whereas no anti\u2010TG IgG from healthy individuals reacted with this region. Affinity columns of Sepharose\u2010bound intravenous therapeutic immunoglobulins which contain anti\u2010T44 activity, retained both T44 Id\u2010expressing antibodies and a subset of region II\u2010specific anti\u2010TG autoantibodies from patients with Hashimoto's disease. Restricted idiotypic and epitopic specificity may demarcate disease\u2010associated from natural anti\u2010TG autoantibodies, suggesting that qualitative rather than quantitative criteria should be used to identify pathological autoantibodies.<\/jats:p>","DOI":"10.1002\/eji.1830210340","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T12:39:06Z","timestamp":1172752746000},"page":"811-814","source":"Crossref","is-referenced-by-count":29,"title":["Evidence for a restricted idiotypic and epitopic specificity of anti\u2010thyroglobulin autoantibodies in patients with autoimmune thyroiditis"],"prefix":"10.1002","volume":"21","author":[{"given":"Gilles","family":"Dietrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel D.","family":"Kazatchkine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Piechaczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Pau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(87)90117-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.4049\/jimmunol.143.4.1129","volume":"143","author":"Bouanani M.","year":"1989","journal-title":"J. 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