{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T08:40:34Z","timestamp":1698223234968},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":5349,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IgG antibodies and eosinophils kill schistosomula of <jats:italic>Schistosoma mansoni in vitro<\/jats:italic>, and there is now evidence to suggest that the main factor that contributes to the expression of purified IgG effector function is the degree of activation of the donor's eosinophils. This study was designed to identify serum\u2010derived activating factors in sera from individuals infected with <jats:italic>S. mansoni.<\/jats:italic> Such activating factors may be responsible for enhancing eosinophil cytotoxicity against schistosomula. Serum\u2010borne mediators were prepared by fractionation of sera from infected individuals by gel filtration high\u2010performance liquid chromatography. The eosinophil\u2010stimulating activity of these mediators was assayed by a new method which depends on the increased expression of the CR3 \u03b1 chain (CD11b) on the surface of activated eosinophils. Sera from infected individuals exhibited different levels of eosinophil activation, and activation appeared to be due to several serum factors, including interleukin 5. In conclusion, our results suggest that eosinophil\u2010activating factors present in infection sera may not only be responsible for enhancing eosinophil cytotoxicity but also be necessary for its expression.<\/jats:p>","DOI":"10.1002\/eji.1830210407","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T12:38:41Z","timestamp":1172752721000},"page":"901-905","source":"Crossref","is-referenced-by-count":8,"title":["The presence of eosinophil\u2010activating mediators in sera from individuals with <i>Schistosoma mansoni<\/i> infections"],"prefix":"10.1002","volume":"21","author":[{"given":"Graziella","family":"Mazza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kareen J. 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