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All B cells present in the IL 4 transgenic mice show a marked increase in expression of class II histocompatibility (Ia) antigens compared to B cells from control mice. <jats:italic>In vivo<\/jats:italic> 5\u2010bromo\u20102\u2032\u2010deoxyuridine incorporation and cell cycle analysis revealed no significant increase in B cell proliferation in spleens of IL 4 transgenic mice compared to littermate controls. Likewise, serum immunoglobulin concentrations in IL4 transgenic mice were not increased. From these experiments we conclude that Ia hyperexpression on B cells <jats:italic>per se<\/jats:italic> does not induce activation of autoreactive T cells leading to B cell proliferation or hypergammaglobulinemia.<\/jats:p>","DOI":"10.1002\/eji.1830210410","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T12:38:41Z","timestamp":1172752721000},"page":"921-925","source":"Crossref","is-referenced-by-count":31,"title":["Major histocompatibility complex class II hyperexpression on B cells in interleukin 4\u2010transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia"],"prefix":"10.1002","volume":"21","author":[{"given":"Werner","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"K\u00fchn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Rajewsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1198"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(85)90015-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1986.tb20874.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.4049\/jimmunol.129.3.1219","volume":"129","author":"Raveche E. 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