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Injections into normal mice of Ig isolated from normal mouse serum, resulted in a dose\u2010dependent and reversible reduction in numbers of BM B lineage cells, in particular of small B220<jats:sup>+<\/jats:sup> surface IgM<jats:sup>\u2212<\/jats:sup> cells. Maximal effects were observed upon injection of isologous polyclonal Ig and were independent of mature T cells. These results suggest a feedback modulation of peripheral Ig on cellular activities in BM B lineage compartments, mediated by mechanisms that seem to involve the variable regions of the Ig molecule.<\/jats:p>","DOI":"10.1002\/eji.1830210510","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T12:50:04Z","timestamp":1172753404000},"page":"1155-1161","source":"Crossref","is-referenced-by-count":40,"title":["Normal serum immunoglobulins influence the numbers of bone marrow pre\u2010B and B cells"],"prefix":"10.1002","volume":"21","author":[{"given":"Anne","family":"Sundblad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Marcos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Huetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Heusser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Portnoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(74)90233-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.4049\/jimmunol.131.6.2635","volume":"131","author":"Opstelten D.","year":"1983","journal-title":"J. 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