{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T05:59:13Z","timestamp":1698299953723},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":5038,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In humans the majority of the CD3<jats:sup>+<\/jats:sup> T cells usually express an \u03b1\/\u00df T cell receptor (TcR) and a minority express a \u03b3\/\u03b4 TcR. The CD3<jats:sup>+<\/jats:sup> TcR \u03b1\/\u00df and CD3<jats:sup>+<\/jats:sup> TcR \u03b3\/\u03b4 cells from blood of the patients with schistosomiasis with carcinoma of the urinary bladder (SCB) were analyzed for phenotype, activation, secretion of interleukin 2 (IL2), B cell growth factor (BCGF) and B cell differentiation factor (BCGF), as well as for autologous (AMLR) and allogeneic (MLR) mixed lymphocyte reaction. Patients with SCB had a highly increased percentage of CD3<jats:sup>+<\/jats:sup> TcR\u03b3\/\u03b4 and a decreased percentage of CD3<jats:sup>+<\/jats:sup> TcR \u03b3\/\u00df T cells in their circulation. These CD3<jats:sup>+<\/jats:sup> TcR \u03b3\/\u03b4 T cells expressed the CD25 (IL 2 receptor), CD38, CD71 (transferrin receptor) and HLA\u2010DR activation antigens at a higher intensity after <jats:italic>in vitro<\/jats:italic> stimulation with recombinant IL 2, phytohemagglutinin and soluble egg antigen (from <jats:italic>Schistosoma haematobium<\/jats:italic>). The SCB patients' CD3<jats:sup>+<\/jats:sup> TcR \u03b3\/\u03b4 T cells were highly deficient in secretion of IL 2 but produced highly elevated levels of BCGF and BCDF. On the contrary, both BCGF and BCDF activities of the CD3<jats:sup>+<\/jats:sup> TcR \u03b1\/\u03b2 T cells were decreased. Moreover, CD3<jats:sup>+<\/jats:sup> TcR \u03b3\/\u03b4 T cells demonstrated highly deficient AMLR and MLR activity. These observations suggest a possible role of CD3<jats:sup>+<\/jats:sup> TcR \u03b3\/\u03b4 T cells in the immune response and the disease pathogenesis in human schistosomiasis infections.<\/jats:p>","DOI":"10.1002\/eji.1830220204","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T13:56:14Z","timestamp":1172757374000},"page":"309-314","source":"Crossref","is-referenced-by-count":14,"title":["Phenotype, activation and lymphokine secretion by \u03b3\/\u03b4 T lymphocytes from schistosomiasis and carcinoma of the urinary bladder"],"prefix":"10.1002","volume":"22","author":[{"given":"Syed","family":"Raziuddin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sugandh","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1982.tb00377.x"},{"key":"e_1_2_1_3_2","first-page":"527","volume-title":"Immunology of Parasitic Infections","author":"Smithers S. 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