{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:59:14Z","timestamp":1760266754322},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":4978,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MRL\/MP\u2010<jats:italic>lpr\/lpr<\/jats:italic> mice are homozygous for the <jats:italic>lpr<\/jats:italic> mutation that results in the accumulation of phenotypically abnormal cells (CD3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>CD8<jats:sup>\u2212<\/jats:sup>) in all lymphoid issues. Although no major abnormalities in the T cell receptor repertoire expressed by such <jats:italic>lpr<\/jats:italic> cells have been reported, the <jats:italic>lpr<\/jats:italic> mutation is a major disease\u2010accelerating factor. Finally, intravenous administration of irradiated <jats:italic>lpr<\/jats:italic> cells recovered from the hyperplastic lymph nodes of adult diseased animals to young MRL\/Mp\u2010<jats:italic>lpr\/lpr<\/jats:italic> mice resulted in a highly significant amelioration of disease parameters. This \u201cT cell vaccination\u201d approach resulted in a selective depletion of cells expressing products of the V<jats:sub>\u03b2<\/jats:sub>8.2 subfamily among lymph node T cells, in addition to eliciting a surge in peripheral T cells capable of conferring disease protection in adoptive transfer experiments. Thus, a strategy aimed at specifically reducing the frequency of <jats:italic>lpr<\/jats:italic> cells proved successful in mitigating the autoimmune process. These findings add to the involvement of <jats:italic>lpr<\/jats:italic> cells in the autoimmune process and constitute the first report that T cell vaccination may be beneficial to a spontaneously occurring autoimmune disease.<\/jats:p>","DOI":"10.1002\/eji.1830220432","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T14:35:32Z","timestamp":1172759732000},"page":"1089-1093","source":"Crossref","is-referenced-by-count":26,"title":["<i>Ipr<\/i> T cells vaccinate against lupus in MRL\/<i>lpr<\/i> mice"],"prefix":"10.1002","volume":"22","author":[{"given":"Ignacio M.","family":"de Albor\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 C.","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Gonzalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 L.","family":"Andreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A. 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