{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:26:10Z","timestamp":1756895170098},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4968,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transfer of encephalitogenic, CD4<jats:sup>+<\/jats:sup> T lymphocyte lines into syngeneic adult Lewis rats not only leads to the development of experimental autoimmune encephalomyelitis (EAE), but, in addition, to the expansion of counterregulatory, CD8<jats:sup>+<\/jats:sup> T lymphocyte clones which are able to lyse specifically the encephalitogenic T cells <jats:italic>in vitro<\/jats:italic> and to neutralize their encephalitogenic capacity <jats:italic>in vivo<\/jats:italic>. In striking contrast, in neonatal rats, which still lack myelin (autoantigens), injection of the same encephalitogenic lines neither mediates EAE, nor confers protection in later life against the myelin\u2010specific T cells. In fact, this treatment results in the life\u2010long functional elimination of counterregulatory, clonotypic CD8<jats:sup>+<\/jats:sup> T lympholcytes, which cannot even be reinduced by repeated injections of the relevant CD4<jats:sup>+<\/jats:sup> T line. These data seem to point to a self\u2010protective T cell control mechanism which is developed within the immune system prior to, and thus independent of the appearance of the appropriate self antigen.<\/jats:p>","DOI":"10.1002\/eji.1830220513","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T17:34:50Z","timestamp":1172770490000},"page":"1193-1198","source":"Crossref","is-referenced-by-count":13,"title":["Immune regulation in self tolerance: functional elimination of a self\u2010reactive, counterregulatory CD8<sup>+<\/sup> T lymphocyte circuit by neonatal transfer of encephalitogenic CD4<sup>+<\/sup> T cells lines"],"prefix":"10.1002","volume":"22","author":[{"given":"Yufen","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deming","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Wekerle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90044-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830110307"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.4049\/jimmunol.135.5.3128","volume":"135","author":"Schluesener H. 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