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The CD5<jats:sup>+<\/jats:sup> B cells expressed CD11b (Mac\u20101). Another small subpopulation of B cells carried CD11b but not CD5. In cattle infected with <jats:italic>Trypanosoma congolense<\/jats:italic>, a dramatic increase in the percentage of CD5<jats:sup>+<\/jats:sup> B cells in blood and spleen was observed. This increase occurred 7\u201010 days after parasites were first detected in the blood and correlated with the increase in serum IgM and the increase in the absolute number of B cells that is typical to trypanosome\u2010infected animals. The increase in B cells was found to be due mainly to the expansion of the CD5<jats:sup>+<\/jats:sup> B cell subpopulation. The cause of the amplification of the CD5<jats:sup>+<\/jats:sup> B cells and their possible involvement in the production of autoantibodies and non\u2010parasite\u2010specific antibodies which have been described in trypanosome\u2010infected animals are discussed.<\/jats:p>","DOI":"10.1002\/eji.1830220708","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T16:29:52Z","timestamp":1172766592000},"page":"1713-1718","source":"Crossref","is-referenced-by-count":54,"title":["Characterization and measurement of CD5<sup>+<\/sup> B cells in normal and <i>Trypanosoma congolense<\/i>\u2010infected cattle"],"prefix":"10.1002","volume":"22","author":[{"given":"Jan","family":"Naessens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana J. 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