{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:50:36Z","timestamp":1790419836029,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T00:00:00Z","timestamp":1134000000000},"content-version":"vor","delay-in-days":4908,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously identified IgM autoantibodies in the sera of patients with Wiskott\u2010Aldrich syndrome (WAS) that react with a subset of normal human B lymphocytes and induce B cell differentiation <jats:italic>in vitro.<\/jats:italic> From splenocytes of a patient with WAS we generated heterohybridomas (HY18 and HY21) and a lymphoblastoid cell line (LWA10) that produce human IgM \u03bb or IgM \u03c7 anti\u2010B lymphocyte autoantibodies, respectively. Immunohistochemical and multiparameter flow cytometric analyses demonstrate that these autoantibodies are specific for lymphocytes of the B lineage and preferentially stain B cells that reside in the mantle zone of secondary follicles and that constitutively co\u2010express the CD5 surface antigen and most major autoantibody\u2010associated cross\u2010reactive idiotypes; in addition, these antibodies stain most pre\u2010B cells in adult bone marrow. Molecular studies show that these anti\u2010B lymphocyte autoantibodies are encoded by a highly conserved V<jats:sub>H<\/jats:sub>4 gene, designated V<jats:sub>H<\/jats:sub>4.21. The gene encodes a number of autoantibodies, especially anti\u2010i and anti\u2010I IgM cold agglutinins. Hemagglutination and surface labeling studies reveal that HY18 and LWA10 recognize the \u201ci\u201d carbohydrate antigenic determinant(s) which is classically found on human cord red blood cells and, as shown now by this study, on a subpopulation of human B cells which expresses it early in B cell development. These studies raise the possibility that the gene product encoded by this highly conserved germ\u2010line V<jats:sub>H<\/jats:sub>4 gene may play a physiological role in B cell development and\/or differentiation.<\/jats:p>","DOI":"10.1002\/eji.1830220717","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T16:29:52Z","timestamp":1172766592000},"page":"1781-1788","source":"Crossref","is-referenced-by-count":40,"title":["An anti\u2010B cell autoantibody from Wiskott\u2010Aldrich syndrome which recognizes i blood group specificity on normal human B cells"],"prefix":"10.1002","volume":"22","author":[{"given":"Catherine","family":"Grillot\u2010Courvalin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Claude","family":"Brouet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvaine","family":"Labaume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Piller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Z.","family":"Rassenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg J.","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Kipps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Silberstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.2.653"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.4.1151"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.4049\/jimmunol.142.2.439","volume":"142","author":"Glotz D.","year":"1989","journal-title":"J. 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