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Evaluation of various LCMV isolates in this study established a general correlation between their tropism for lymphohemopoietic cells and immunosuppression. When immune responses were assessed as the capacity of mice to mount an anti\u2010vaccinia virus cytotoxic T cell response or an IgG response to vesicular stomatitis virus (VSV), after a primary LCMV infection, LCMV\u2010Armstrong, WE, Clone 13 and Docile were increasingly immunosuppressive in a dose\u2010dependent fashion with respect to both extent and duration. Analysis of lymphocyte subpopulations showed variable effects of the various LCMV isolates that did not reveal patterns readily explaining immunosuppression. To evaluate whether LCMV infection affected T and\/or B cell functions directly or whether antigen presentation was impaired, adoptive transfer experiments were performed. Untreated or irradiated but uninfected normal recipient mice receiving adoptively transferred T or B cells from LCMV\u2010WE or Docile\u2010infected immunosuppressed donor mice responded within 30%\u2013100% of normal ranges in both assay systems. In contrast, when T or B cells from normal donors were transferred to irradiated or non\u2010irradiated LCMV\u2010immunosuppressed recipients, they failed to mount a significant cytotoxic T cell response against vaccinia virus or an IgG response to VSV. Thus, the T and B cells from LCMV\u2010immunosuppressed mice were able to function within normal ranges; in contrast, histologically and functionally, antigen presentation was severely impaired in LCMV\u2010immunosuppressed mice.<\/jats:p>","DOI":"10.1002\/eji.1830220720","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T16:29:52Z","timestamp":1172766592000},"page":"1803-1812","source":"Crossref","is-referenced-by-count":54,"title":["Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation"],"prefix":"10.1002","volume":"22","author":[{"given":"Alana","family":"Althage","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Odermatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demetrius","family":"Moskophidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"K\u00fcndig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs Hoffman\u2010Rohrer Hans","family":"Hengartner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf M.","family":"Zinkernagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1962.027.001.046"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.4049\/jimmunol.101.4.717","volume":"101","author":"Mims C. 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