{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:52:35Z","timestamp":1770702755435,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":4770,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The binding of interleukin (IL)\u20101\u03b1, IL\u20101\u03b2, IL\u20102 and IL\u20106 to acidic polysaccharides was investigated by affinity chromatography of the recombinant, radioiodinated interleukins on columns of immobilized polysaccharide. Each interleukin showed selective binding retention. Overall heparin bound all four interleukins significantly, whereas chondroitin sulfate provided little retention. IL\u2010\u03b1 and IL\u20101\u03b2 showed differential binding, with only the latter binding to hyaluronic acid. IL\u20102 was virtually completely retained on fucoidan. Noniodinated recombinant IL\u20102 bound similarly to fucoidan, and fucoidan was found to sequester IL\u20102 activity in a bioassay employing IL\u20102\u2010dependent CTLL cells. In all other cases tested, interleukin retention was partial, implying that interleukin binding sites are sparsely distributed along the polysaccharide chains. These findings suggest that during the immune response, interleukins will tend to be retained at sites of secretion by interaction with glycosaminoglycans in the extracellular matrix and on cell surfaces.<\/jats:p>","DOI":"10.1002\/eji.1830221139","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T13:11:40Z","timestamp":1172754700000},"page":"3027-3031","source":"Crossref","is-referenced-by-count":106,"title":["Selective and differential binding of interleukin (IL)\u20101\u03b1, IL\u20101\u03b2, IL\u20102 and IL\u20106 to glycosaminoglycans"],"prefix":"10.1002","volume":"22","author":[{"given":"Lawrence","family":"Ramsden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90085-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/326403a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/332376a0"},{"key":"e_1_2_1_5_2","first-page":"766","volume":"2","author":"Keating A.","year":"1988","journal-title":"Leukaemia"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0180962"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.96.3.722"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.4049\/jimmunol.145.11.3747","volume":"145","author":"Borth W.","year":"1990","journal-title":"J. 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