{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:03:42Z","timestamp":1778630622474,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":4740,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experiments with transgenic mice expressing the glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV) under the control of the rat insulin promoter (RIP) have demonstrated that potentially self\u2010reactive T cells that normally ignore self peptides may nevertheless be induced by self peptides or \u201ccross\u2010reactive\u201d foreign (<jats:italic>e.g.<\/jats:italic> viral) peptides that arise in the host in an immunogenic form; once activated these potentially self\u2010reactive T cells may cause autoaggressive diseases (<jats:italic>e.g.<\/jats:italic> diabetes). The possibility of vaccinating against such T cell\u2010mediated immunopathological diseases was evaluated in the RIP\u2010GP transgenic mouse line Bln. Any attempt to vaccinate with the self antigen itself (<jats:italic>e.g.<\/jats:italic> recombinant vaccinia virus expressing LCMV\u2010GP) failed to protect mice from disease. However, immunization with a recombinant vaccinia virus expressing LCMV\u2010nucleoprotein (vacc\u2010NP) as a non\u2010GP LCMV vaccine was able to modulate the immune response and prevented autoaggressive disease in a MHC\u2010dependent fashion. In contrast, tolerance induction neonatally or, more generally applicable, by lethal irradiation and reconstitution with neo\u2010self antigen\u2010expressing bone marrow cells always resulted in prevention of virally induced diabetes in this model situation.<\/jats:p>","DOI":"10.1002\/eji.1830221218","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T13:11:23Z","timestamp":1172754683000},"page":"3149-3153","source":"Crossref","is-referenced-by-count":16,"title":["Vaccination or tolerance to prevent diabetes"],"prefix":"10.1002","volume":"22","author":[{"given":"Stephan","family":"Oehen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela S.","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Aichele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"B\u00fcrki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Hengartner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf M.","family":"Zinkernagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","volume-title":"The production of antibody (Monogr.)","author":"Burnet F. 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