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When these mice were treated for 4 weeks after immunization with 1 mg\/week of a monoclonal antibody (mAb) that neutralizes the activity of interferon\u2010\u03b3 (IFN) a beneficial effect on the onset of EAT was observed. Characteristic features of EAT were significantly reduced, including the lymphocytic infiltrations of the thyroid glands and the serum levels of autoantibodies to Tg. Moreover, in lymphoid organs, mAb to IFN\u2010\u03b3 significantly reduced the percentages of Tg\u2010specific CD8<jats:sup>+<\/jats:sup> cells, labeled by the anti\u2010clonotypic mAb AG7. These Tg\u2010specific T cells seem responsible for thyroid damages and disease development, since EAT was simultaneously abrogated.<\/jats:p><jats:p>These results show that IFN\u2010\u03b3 plays an essential role in the pathophysiology of EAT and suggest the possibility to treat autoimmune thyroid diseases with mAb to IFN\u2010\u03b3 or drugs able to antagonize the production and\/or the action of this cytokine.<\/jats:p>","DOI":"10.1002\/eji.1830230143","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T17:49:43Z","timestamp":1172771383000},"page":"275-278","source":"Crossref","is-referenced-by-count":63,"title":["The effects of a monoclonal antibody to interferon\u2010\u03b3 on experimental autoimmune thyroiditis (EAT): prevention of disease and decrease of EAT\u2010specific T cells"],"prefix":"10.1002","volume":"23","author":[{"given":"Haiwen","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Mignon\u2010Godefroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Luigi","family":"Meroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Garotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannine","family":"Charreire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60656-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-10-4-537"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1985.tb00449.x"},{"key":"e_1_2_1_5_2","first-page":"265","volume":"61","author":"Todd I.","year":"1985","journal-title":"Clin. 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