{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:08:04Z","timestamp":1770750484098,"version":"3.50.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":4605,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intraepithelial lymphocytes (IEL) of the uterus of non\u2010pregnant sheep were analyzed by single\u2010 and two\u2010color flow cytometry. Very few lymphocytes carrying classical B and T cell markers (CD5, surface immunoglobulin) were detected in the uterine epithelial cell suspensions and all IEL expressed the CD8 surface marker although with varying intensities. Three distinct subpopulations were identified including a major (46\u201056%) population of CD8<jats:sup>+<\/jats:sup>CD45R<jats:sup>\u2212<\/jats:sup>\u03b3\u03b4 T cell receptor (TcR)\u2010negative cells and approximately equal numbers of CD8<jats:sup>+<\/jats:sup>CD45R+\u03b3\u03b4TcR<jats:sup>\u2212<\/jats:sup> and CD8<jats:sup>+<\/jats:sup>CD45R<jats:sup>+<\/jats:sup>\u03b3\u03b4TcR<jats:sup>+<\/jats:sup> lymphocytes. The same three subpopulations were also present in the interplacentomal areas of the uterus of ewes at a late stage of pregnancy but there was a dramatic increase (60\u201070%) in the \u03b3\u03b4 TcR<jats:sup>+<\/jats:sup> subpopulation. In addition, a pronounced increase in both size and granularity was observed in the IEL population of pregnant uteri and this was attributed to the \u03b3\u03b4 TcR<jats:sup>+<\/jats:sup> cells. Light and electron microscopic examination of these \u03b3\u03b4 TcR<jats:sup>+<\/jats:sup> IEL revealed an increase in metabolic activity and the formation of exceptionally large cytoplasmic granules and confirmed their restricted localization within the uterine epithelium close to the trophoblast. These results represent for the first time, a clear example of the activation of \u03b3\u03b4 TcR<jats:sup>+<\/jats:sup> cells which is not associated with an ongoing disease process or infection, \u03b3\u03b4 TcR<jats:sup>+<\/jats:sup> cells have recently been observed in the epithelium of the murine reproductive tract and were characterized by their unique homogeneous receptor structure. The present results indicate that these cells may play an important physiological role during pregnancy.<\/jats:p>","DOI":"10.1002\/eji.1830230520","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T19:06:21Z","timestamp":1172775981000},"page":"1112-1117","source":"Crossref","is-referenced-by-count":84,"title":["Activation of uterine intraepithelial \u03b3\u03b4 T cell receptor\u2010positive lymphocytes during pregnancy"],"prefix":"10.1002","volume":"23","author":[{"given":"Els","family":"Meeusen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Brandon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee\u2010Seong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90109-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91267-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/343754a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90326-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.3.683"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.1.239"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90375-H"},{"key":"e_1_2_1_9_2","first-page":"157","volume":"63","author":"Lee C. 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