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LCMV infection of TCR transgenic mice induced LCMV\u2010specific effector and memory T cells whereas injection of soluble LCMV glycoprotein peptide 33\u201041 resulted in tolerance by peripheral deletion and anergy of LCMV\u2010specific T cells after an initial expansion phase. Similarly, LCMV peptide 33\u201041\u2010specific tolerance could be achieved in normal C57BL\/6 mice and was not abrogated by an LCMV infection. These results obtained with a classically MHC\u2010restricted peptide antigen parallel previous findings with retroviral or bacterial superantigens and indicate a possibility to modulate specifically mature peripheral cytotoxic T lymphocytes <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.1830230834","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T19:24:22Z","timestamp":1172777062000},"page":"1956-1962","source":"Crossref","is-referenced-by-count":168,"title":["T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides"],"prefix":"10.1002","volume":"23","author":[{"given":"Diego","family":"Kyburz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Aichele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Speiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hengartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf M.","family":"Zinkemagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1988.tb00737.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.002531"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90567-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/332035a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/332040a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90980-X"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/339541a0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90420-J"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.4.1091"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.4.1065"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90700-O"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90388-U"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1989.tb00003.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/342559a0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1966.tb12851.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/346629a0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.4049\/jimmunol.148.4.1003","volume":"148","author":"Luescher I. 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