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We found that triggering of B cells by an anti\u2010CD40 monoclonal antibody or the soluble CD40 ligand plus interleukin (IL)\u20104 or IL\u201010 led to B cell proliferation and\/or differentiation towards IgG, IgA and IgE secretion. This was reflected by transcription of C\u03b3, \u03b1 and \u03b5 membrane isotype expression and IgG, IgA and IgE production. These results confirm the integrity of B cells in patients with the HIGM1 immunodeficiency and open up new therapeutic possibilities.<\/jats:p>","DOI":"10.1002\/eji.1830230936","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T19:24:01Z","timestamp":1172777041000},"page":"2294-2299","source":"Crossref","is-referenced-by-count":72,"title":["Induction by anti\u2010CD40 antibody or soluble CD40 ligand and cytokines of IgG, IgA and IgE production by B cells from patients with X\u2010linked hyper IgM syndrome"],"prefix":"10.1002","volume":"23","author":[{"given":"Anne","family":"Durandy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Schiff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Yves","family":"Bonnefoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Forveille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Rousset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Mazzei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Milili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830221016"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1702555"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830190818"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.4049\/jimmunol.149.12.3817","volume":"149","author":"Lederman S.","year":"1992","journal-title":"J. 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