{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:49:06Z","timestamp":1790110146434,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4450,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>BLR1<\/jats:italic> gene, isolated initially from Burkitt lymphoma cells (<jats:italic>Eur. J. Immunol.<\/jats:italic> 1992. <jats:italic>22<\/jats:italic>:2795), encodes a G protein\u2010coupled receptor with significant relationship to receptors for chemokines (IL\u20108, MIP\u20101\u03b1) and neuropeptides. The murine homologue of human <jats:italic>BLR1<\/jats:italic> was cloned and used to investigate its expression <jats:italic>in vivo. Brl1<\/jats:italic>\u2010specific transcripts are observed in secondary lymphatic organs and to a lesser extent in brain of adult mice but not in other tissues. RNA <jats:italic>in situ<\/jats:italic> hybridization localizes <jats:italic>blr1<\/jats:italic> transcription to primary follicles and to the mantle zone of secondary follicles. SCID mice in which mature B cell development is severely impaired exhibit a strongly reduced level of <jats:italic>blr1<\/jats:italic>\u2010specific RNA in the spleen. The analysis of murine lymphoid tumor cell lines representing distinct stages of the B cell lineage reveals elevated expression of <jats:italic>blr1<\/jats:italic> in B cell lymphomas but not in pre\u2010B lymphomas or plasmacytomas. Induction of differentiation of resting B cells by cytokines or mitogens down\u2010regulates expression of <jats:italic>blr1.<\/jats:italic> RNA <jats:italic>in situ<\/jats:italic> hybridization using brain sections of adult mice detects <jats:italic>blr1<\/jats:italic> transcription in the granule and Purkinje cell layer of the cerebellum. Interestingly, the <jats:italic>blr1<\/jats:italic> gene is also expressed during late embryogenesis in fetal liver and brain. In view of the remarkable expression pattern in the B cell lineage we suggest that murine BLR1 may represent a cytokine\/neuropeptide receptor exerting regulatory functions on recirculating mature B lymphocytes.<\/jats:p>","DOI":"10.1002\/eji.1830231023","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T18:36:00Z","timestamp":1172774160000},"page":"2532-2539","source":"Crossref","is-referenced-by-count":57,"title":["The G protein\u2010coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues"],"prefix":"10.1002","volume":"23","author":[{"given":"Edelgard","family":"Kaiser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"F\u00f6rster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Ebensperger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Michael Kuehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60876-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(92)90008-3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1992.tb00635.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(91)90047-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90060-X"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.3.671"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830221226"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05530.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.13.1397843"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830190311"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.16.7410"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.146.2.715"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42487-8"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4049\/jimmunol.149.1.169","volume":"149","author":"Melamed I.","year":"1992","journal-title":"J. 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