{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:17:10Z","timestamp":1770718630758,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4450,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>BALB\/c mice injected at birth with semi\u2010allogeneic F1 spleen cells become tolerant to alloantigens as shown by their CTL unresponsiveness to the corresponding alloantigen and the persistence of donor F1 cells into the BALB\/c host. Moreover, these mice develop a transient systemic lupus erythematosis\u2010like autoimmune syndrome characterized by splenomegaly, glomerulonephritis, thrombocytopenia and abnormal serological findings, such as several autoantibodies and IgG1 hypergammaglobulinemia. Recent studies done in our laboratory have shown that donor F1 B cells persisting in the host are responsible for the production of autoantibodies and must be activated <jats:italic>in vivo<\/jats:italic> by the host CD4<jats:sup>+<\/jats:sup> T lymphocytes in a MHC class II\u2010restricted fashion. In the present work, we have focused our attention on the ability of splenic CD4<jats:sup>+<\/jats:sup> T cells recovered at different periods from BALB\/c mice injected at birth with (CBA\/Ca \u00d7 BALB. Igh<jats:sup>b<\/jats:sup>) Fl spleen cells to interact with and activate F1 semi\u2010allogeneic spleen cells <jats:italic>in vitro.<\/jats:italic> We show that (i) only CD4<jats:sup>+<\/jats:sup> T cells from 2\u2010 and 3\u2010week\u2010old tolerant BALB\/c mice preferentially produce IL\u20104 and IL\u20105 in response to a F1 semi\u2010allogeneic <jats:italic>in vitro<\/jats:italic> stimulation, (ii) CD4<jats:sup>+<\/jats:sup> T cells purified from 3\u2010week\u2010old tolerant BALB\/c mice are able to induce <jats:italic>in vitro<\/jats:italic> IgG and IgM production by F1 B cells. Taken together, these results strongly suggest that host CD4+ T cells, belonging to the TH2 subset progressively lose their reactivity towards the F1 semi\u2010allogeneic persistent B cells, reaching a state of unresponsiveness that correlates with the disappearance of serum autoantibodies and autoimmune pathology.<\/jats:p>","DOI":"10.1002\/eji.1830231026","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T18:36:00Z","timestamp":1172774160000},"page":"2551-2556","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of host CD4<sup>+<\/sup> T lymphocytes in mice neonatally tolerized to alloantigens"],"prefix":"10.1002","volume":"23","author":[{"given":"Giulia","family":"Kramar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Aguado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Louis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Del Giudice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul\u2010Henri","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/172603a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1959.0008"},{"key":"e_1_2_1_4_2","first-page":"2165","volume":"131","author":"Feng H. 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