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In this study, we investigated whether the <jats:italic>Schistosoma<\/jats:italic> gut\u2010associated antigens CAA and CCA (circulating anodic antigen and circulating cathodic antigen, respectively), which are excreted in relatively large quantities into the host's circulation, might play a role in evading complement attack. Of several complement components tested, only purified C1q showed significant binding to CAA, a negatively charged highly glycosylated glycoprotein. CCA, also highly glycosylated, but neutral or slightly positively charged, did not bind to C1q. CAA bound only to the collagen\u2010like stalks of C1q and not to the globular heads. No detectable interaction of CAA with precursor human CI was found and CAA did not induce activation of CI in whole human serum as assessed by consumption of hemolytic C4 activity. Also CAA could not induce activation of precursor CI <jats:italic>in vitro<\/jats:italic>. These results suggest that CAA behaves like a receptor for C1q, and might be involved in protecting the vulnerable schistosome gut against complement\u2010mediated attack.<\/jats:p>","DOI":"10.1002\/eji.1830231113","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T18:30:29Z","timestamp":1172773829000},"page":"2807-2812","source":"Crossref","is-referenced-by-count":18,"title":["<i>Schistosoma mansoni<\/i> circulating anodic antigen but not circulating cathodic antigen interacts with complement component C1q"],"prefix":"10.1002","volume":"23","author":[{"given":"Govert J.","family":"van Dam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Seino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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