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Furthermore, this inactivation was accompanied by proteinase 3\u2010dependent cleavage of the C1 inhibitor into an 83 000 molecular weight fragment. The formation of the 83 000 molecular weight fragment followed a time course which was similar to that observed for the inactivation of hemolytic activity. Within 120 minutes more than 90% of the hemolytic activity was lost. This inactivation of C1 inhibitor appeared to be selective as purified human Clq was not degraded in a similar time period. Moreover, when 100 \u03bcg IgG, isolated from each of 21 Wegener's granulomatosis patients with cytoplasmic anti\u2010nuclear antibodies immunofluoresent titers to proteinase 3 greater then 1:64, was incubated with 3 milliunits of proteinase 3, little to no cleavage of C1 inhibitor was observed. In contrast, 100 \u03bcg of IgG isolated from 14 normal donors was ineffective in affording protection to C1 inhibitor upon incubation with proteinase 3. 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