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The antigen(s) was further resolved to fractions that contained intact Ig or Ig heavy chain since the T cells responded to &gt; 100 kDa and 40\u2010\u201060 kDa polypeptides derived from purified Ig under nonreducing and reducing conditions, respectively. These results indicated that the antigen(s) is either Ig heavy chain or Ig\u2010binding proteins that copurify with Ig and Ig subunits. Pepsin and papain digestion of the antigenic fractions eluted from protein A destroyed the T cell reactivity. Since most Fab regions are resistant to these enzymes, further analyses are required to localize the antigenic epitope(s). The presence of Ig\u2010 or Ig\u2010antigen complex\u2010reactive T cells in arthritic joints implies that B cells expressing anti\u2010Ig antibody (<jats:italic>i.e.<\/jats:italic> rheumatoid factor) may play an important role in antigen presentation to autoreactive T cells.<\/jats:p>","DOI":"10.1002\/eji.1830240115","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T19:23:51Z","timestamp":1172777031000},"page":"93-98","source":"Crossref","is-referenced-by-count":26,"title":["Joint\u2010derived T cells in rheumatoid arthritis react with self\u2010immunoglobulin heavy chains or immunoglobulin\u2010binding proteins that copurify with immunoglobulin"],"prefix":"10.1002","volume":"24","author":[{"given":"Wim C. A.","family":"van Schooten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre","family":"Devereux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Quan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal J. 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