{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:16Z","timestamp":1761058636526},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":4313,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inbred mice infected with <jats:italic>Leishmania major<\/jats:italic> promastigotes display two different courses of leishmaniasis: resistant strains develop self\u2010healing local sores, while susceptible strains show progressive systemic disease with lethal outcome. Resistance predominantly correlates with the production of T helper type 1 (TH1) lymphokines and susceptibility with production of TH2\u2010type lymphokines. Here, we analyzed whether this TH phenotype difference correlates with expression of particular T cell receptor V\u03b2 chains. Our results show that T cells expand strongly during infection in all groups of mice and invariantly express the same V\u03b2 gene families as prior to infection. Our data indicate that TH1 and TH2 cells use similar V\u03b2 gene families, and argue against the engagement of a restricted set of V\u03b2 by dominant determinants associated with <jats:italic>L. major<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.1830240236","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T20:37:00Z","timestamp":1172781420000},"page":"492-495","source":"Crossref","is-referenced-by-count":1,"title":["V\u03b2 gene repertoires in T cells expanded in local self\u2010healing and lethal systemic murine cutaneous leishmaniasis"],"prefix":"10.1002","volume":"24","author":[{"given":"Michael","family":"Lohoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meike","family":"Steinert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"R\u00f6llinghoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Balderas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Argyrios N.","family":"Theofilopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1989.tb00557.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.4049\/jimmunol.135.3.2108","volume":"135","author":"Titus R. 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