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A small subpopulation of normal B cells and chronic lymphocytic leukemia B cells express (analogous to T cells) the transmembrane molecule CD5, a counterstructure of B cell\u2010specific CD72. Numbers of CD5<jats:sup>+<\/jats:sup> B cells are increased in several physiological and pathological conditions. Moreover, CD5<jats:sup>+<\/jats:sup> B cells are being held responsible for the production of autoreactive antibodies and seem to have signaling characteristics distinct from conventional B cells. On T cells, CD5 associates with the T cell receptor CD3 complex and ligation of CD5 leads to the generation of co\u2010stimulatory signals, that act on T cell activation. We here demonstrate that CD5 is associated with the B cell receptor (BCR) complex and serves as substrate for BCR\u2010induced tyrosine kinase activity. Hence, CD5<jats:sup>+<\/jats:sup> B cells have a unique potential to modulate BCR signals.<\/jats:p>","DOI":"10.1002\/eji.1830240406","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T20:12:04Z","timestamp":1172779924000},"page":"812-816","source":"Crossref","is-referenced-by-count":81,"title":["CD5 is associated with the human B cell antigen receptor complex"],"prefix":"10.1002","volume":"24","author":[{"given":"Arjan C.","family":"Lankester","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gijs M. W.","family":"van Schijndel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline L.","family":"Cordell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carel J. 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