{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T09:27:13Z","timestamp":1770802033036,"version":"3.50.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":4224,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Erosive arthritis is a common and feared complication of staphylococcal infection. The reason(s) for the progressive course of the arthritis is unknown. It has been recently established that enterotoxins produced by <jats:italic>Staphylococcus aureus<\/jats:italic> display superantigen properties leading to stimulation of T cells carrying distinct T cell receptor V\u03b2 elements. This finding provides a potential connection between staphylococcal exoproteins and endogenous immune mechanisms participating in the infectious process. We have recently described successful induction of infectious arthritis in mice after intravenous inoculation of a toxic shock syndrome toxin\u20101 (TSST\u20101)\u2010producing <jats:italic>S. aureus<\/jats:italic> LS\u20101 strain. Using this model we have now found a clonal expansion of T cells expressing V\u03b211<jats:sup>+<\/jats:sup> T cell receptor in the synovial tissue of arthritic mice. The role of TSST\u20101 as a superantigen inducing oligoclonal expansion was confirmed in an <jats:italic>in vitro<\/jats:italic> culture system. The expansion of V\u03b211<jats:sup>+<\/jats:sup> T cells proved to be of arthritogenic significance since mice genomically deleted of the V\u03b211<jats:sup>+<\/jats:sup> T cells did not develop arthritis and since pretreatment of healthy mice with anti\u2010CD4 or anti\u2010V\u03b211 monoclonal antibodies inhibited arthritis. In addition, CD4<jats:sup>+<\/jats:sup> and V\u03b211<jats:sup>+<\/jats:sup> T cells showed themselves to be of pathogenic significance in staphylococcal\u2010induced mortality, since mice depleted of such populations showed increased survival. We propose that in hematogenously spread <jats:italic>S. aureus<\/jats:italic>\u2010induced arthritis the TSST\u20101\u2010dependent clonal expansion of CD4<jats:sup>+<\/jats:sup> V\u03b211<jats:sup>+<\/jats:sup> T cells is a driving pathogenic force.<\/jats:p>","DOI":"10.1002\/eji.1830240523","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T21:51:36Z","timestamp":1172785896000},"page":"1161-1166","source":"Crossref","is-referenced-by-count":64,"title":["Clonal expansion of T lymphocytes causes arthritis and mortality in mice infected with toxic shock syndrome toxin\u20101\u2010producing staphylococci"],"prefix":"10.1002","volume":"24","author":[{"given":"Arturo","family":"Abdelnour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Bremell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikard","family":"Holmdahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Tarkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"503","volume":"22","author":"Estarhai J.","year":"1991","journal-title":"Orthop. 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