{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T22:02:28Z","timestamp":1698357748178},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":4171,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the role of V\u03b28<jats:sup>+<\/jats:sup> T cells in the development of lupus\u2010like autoimmune syndrome in MRL\u2010<jats:italic>lpr<\/jats:italic>\/<jats:italic>lpr<\/jats:italic> mice, we treated them with the F23.1 anti\u2010V\u03b28 monoclonal antibody (mAb) from birth to 4 months of age. Here we report that almost complete depletion of V\u03b28<jats:sup>+<\/jats:sup> T cells by the F23.1 mAb treatment neither inhibited nor delayed the development of hypergammaglobulinemia, autoantibody production and autoimmune glomerulonephritis in MRL\u2010<jats:italic>lpr<\/jats:italic>\/<jats:italic>lpr<\/jats:italic> mice. In addition, the F23.1 mAb treatment did not prevent the development of lymphadenopathy and the generation of a CD4<jats:sup>\u2212<\/jats:sup>CD8<jats:sup>\u2212<\/jats:sup> double\u2010negative T cell subset, characteristically accumulating in <jats:italic>lpr<\/jats:italic> lymph nodes. Our results strongly argue against the idea that the V\u03b28<jats:sup>+<\/jats:sup> T cells play a critical role in the development of lupus\u2010like autoimmune syndrome in MRL\u2010<jats:italic>lpr<\/jats:italic>\/<jats:italic>lpr<\/jats:italic> mice.<\/jats:p>","DOI":"10.1002\/eji.1830240741","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T21:30:56Z","timestamp":1172784656000},"page":"1717-1720","source":"Crossref","is-referenced-by-count":5,"title":["Lack of association of V\u03b28<sup>+<\/sup> T cells with lupus\u2010like syndrome in MRL\u2010<i>lpr<\/i>\/<i>lpr<\/i> mice"],"prefix":"10.1002","volume":"24","author":[{"given":"Liliane","family":"Fossati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Merino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lemoine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Izui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"207","volume-title":"Genetic Control of Autoimmune Disease","author":"Murphy E. D.","year":"1978"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1198"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/356314a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4049\/jimmunol.129.6.2612","volume":"129","author":"Morse H. C.","year":"1982","journal-title":"J. Immunol."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.18.7018"},{"key":"e_1_2_1_7_2","first-page":"130","volume":"77","author":"Ohga S.","year":"1989","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916938909019947"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.4049\/jimmunol.147.4.1214","volume":"147","author":"Seki S.","year":"1991","journal-title":"J. Immunol."},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.4049\/jimmunol.151.7.3450","volume":"151","author":"Herron L. R.","year":"1993","journal-title":"J. Immunol."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.6.1431"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220829"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.4049\/jimmunol.134.6.3994","volume":"134","author":"Staerz U. D.","year":"1985","journal-title":"J. Immunol."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.2.452"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220202"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.4049\/jimmunol.136.12.4420","volume":"136","author":"Luzuy S.","year":"1986","journal-title":"J. Immunol."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/5.5.525"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.2.517"},{"key":"e_1_2_1_19_2","first-page":"249","volume-title":"Pathology Annual","author":"Pirani C. L.","year":"1968"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.4049\/jimmunol.147.2.515","volume":"147","author":"Takahashi S.","year":"1991","journal-title":"J. Immunol."},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/331356a0"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114304"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.3.968"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.4049\/jimmunol.136.11.4075","volume":"136","author":"Davidson W. F.","year":"1986","journal-title":"J. Immunol."},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.5.1713"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830240741","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830240741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T09:21:18Z","timestamp":1695720078000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830240741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1002\/eji.1830240741"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830240741","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}