{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:38:18Z","timestamp":1790491098377,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":4140,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have evaluated the effects of a treatment with soluble interleukin\u20101 receptor (sIL\u20101R) in the accelerated model of autoimmune diabetes induced by cyclophosphamide (CY) in the non\u2010obese diabetic (NOD) mouse. Prior to the CY challenge (350 mg\/kg body weight), female euglycemic NOD mice were randomly divided into three groups (A\u2013C). Groups B and C were treated daily from 1 day before to 13 days after the CY challenge with sIL\u20101R at doses of 0.2 and 2 mg\/kg body weight. Group A was treated with PBS. By 2 weeks after CY administration, an acute form of autoimmune diabetes with glycosuria, hyperglycemia and severe insulitis occurred in the majority (13\/20, 65%) of the control mice (group A). In contrast, repeated injections with sIL\u20101R protected NOD mice from insulin\u2010dependent diabetes mellitus (IDDM) development in a dose\u2010dependent fashion; the incidence of IDDM was 53.3% (8\/15) in the mice treated with 0.2 mg\/kg and only 6.7% (1\/15) in those treated with 2 mg\/kg. However, none of the doses of the sIL\u20101R reduced the extent of insulitis in NOD mice. Importantly, the anti\u2010diabetogenic property of sIL\u20101R may not involve major T cell function impairment; accordingly, in parallel experiments, splenic lymphoid cells from NOD mice not challenged with CY, but treated with 2 mg\/kg sIL\u20101R for 5 consecutive days showed a normal distribution of mononuclear cell subsets and maintained their capacity to secrete interferon\u2010\u03b3 and IL\u20102 and to proliferate in response to polyclonal mitogenic stimulation with concanavalin A.<\/jats:p>","DOI":"10.1002\/eji.1830240818","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T23:16:16Z","timestamp":1172790976000},"page":"1843-1847","source":"Crossref","is-referenced-by-count":72,"title":["Protection from experimental autoimmune diabetes in the non\u2010obese diabetic mouse with soluble interleukin\u20101 receptor"],"prefix":"10.1002","volume":"24","author":[{"given":"Ferdinando","family":"Nicoletti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"di Marcou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma","family":"Barcelliniu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Magro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans U.","family":"Schorlemmeru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Kurrleu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Lunettau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Zacconeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Meronif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(89)90150-5"},{"key":"e_1_2_1_3_2","first-page":"1","volume":"72","author":"Bach J. 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