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We describe a peptide from disease\u2010associated HLA class I antigens sharing sequence homologies with a highly uveitogenic epitope from the retinal autoantigen S\u2010antigen. S\u2010antigen induces autoimmune uveitis in the animal model and is a major autoantigen in human disease. The HLA peptide induced uveitis in the Lewis rat and, moreover, suppressed S\u2010antigen\u2010induced disease when administered orally. Patients' PBL cross\u2010reacted with the HLA\u2010 and corresponding retinal peptide, explaining the organ specificity of the disease.<\/jats:p>","DOI":"10.1002\/eji.1830241103","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T19:54:10Z","timestamp":1172778850000},"page":"2579-2585","source":"Crossref","is-referenced-by-count":88,"title":["Cross\u2010reactivity between an HLA\u2010B27\u2010derived peptide and a retinal autoantigen peptide: a clue to major histocompatibility complex association with autoimmune disease"],"prefix":"10.1002","volume":"24","author":[{"given":"Gerhild","family":"Wildner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan R.","family":"Thurau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91090-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(82)90069-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.59.5.270"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(76)90680-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/jama.1978.03290060031006","volume":"240","author":"Ohno S.","year":"1978","journal-title":"J. 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