{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:00:18Z","timestamp":1774659618897,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":4018,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Blocking the interleukin\u20102 receptor's \u03b1\u2010chain in lymphocytic choriomeningitis virus\u2010infected mice by treatment with monoclonal antibodies diminished the increase of numbers of CD8<jats:sup>+<\/jats:sup> T lymphocytes in spleens and prevented CD8<jats:sup>+<\/jats:sup> T lymphocyte\u2010mediated virus clearance from organs as well as generation of virus\u2010specific cytotoxic T lymphocytes. Also, the CD8<jats:sup>+<\/jats:sup> T cell\u2010mediated early phase of the delayed\u2010type hypersensitivity footpad swelling reaction was decreased. The same treatment had no effect on the number of CD4<jats:sup>+<\/jats:sup> spleen T lymphocytes, which, however, did not enlarge during infection, but these cells' heightened DNA synthesis and cytokine production were reduced by antibody treatment; yet the generation of antiviral antibodies remained unaffected, and the CD4<jats:sup>+<\/jats:sup> T lymphocyte\u2010mediated second part of the footpad reaction was somewhat augmented. We conclude that blocking of the interleukin\u20102 receptor by antibody in lymphocytic choriomeningitis virus\u2010infected mice diminishes both CD8<jats:sup>+<\/jats:sup> and CD4<jats:sup>+<\/jats:sup> T cell\u2010mediated antiviral immune responses, the former more than the latter.<\/jats:p>","DOI":"10.1002\/eji.1830241227","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T19:52:12Z","timestamp":1172778732000},"page":"3093-3099","source":"Crossref","is-referenced-by-count":10,"title":["T lymphocyte\u2010mediated antiviral immune responses in mice are diminished by treatment with monoclonal antibody directed against the interleukin\u20102 receptor"],"prefix":"10.1002","volume":"24","author":[{"given":"Olaf","family":"Uterm\u00f6hlen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"T\u00e1rnok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"B\u00f6nig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz","family":"Lehmann\u2010Grube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3131876"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(91)90028-Y"},{"key":"e_1_2_1_4_2","first-page":"163","volume":"1114","author":"Minami Y.","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80055-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90152-G"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90335-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235625"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.81.2105.439-a"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"608","DOI":"10.4049\/jimmunol.134.1.608","volume":"134","author":"Lehmann\u2010Grube F.","year":"1985","journal-title":"J. Immunol."},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.4049\/jimmunol.133.4.1970","volume":"133","author":"Ortega R. G.","year":"1984","journal-title":"J. Immunol."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.135.6.3988"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830170813"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/312548a0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.4049\/jimmunol.149.10.3331","volume":"149","author":"Gegin C.","year":"1992","journal-title":"J. Immunol."},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.4049\/jimmunol.132.6.2775","volume":"132","author":"Pierres A.","year":"1984","journal-title":"J. Immunol."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1979.tb00289.x"},{"key":"e_1_2_1_18_2","first-page":"181","volume":"14","author":"Brunner K. T.","year":"1968","journal-title":"Immunology"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990110203"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-8-1883"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.4049\/jimmunol.133.6.3366","volume":"133","author":"Moskophidis D.","year":"1984","journal-title":"J. Immunol."},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.4049\/jimmunol.144.7.2847","volume":"144","author":"Leist T. P.","year":"1990","journal-title":"J. Immunol."},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.18.5694"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830170706"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.4049\/jimmunol.117.5_Part_1.1495","volume":"117","author":"Zinkernagel R. M.","year":"1976","journal-title":"J. Immunol."},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1128\/jvi.61.6.1867-1874.1987","volume":"61","author":"Moskophidis D.","year":"1987","journal-title":"J. Virol."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60262-X"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.4049\/jimmunol.144.5.1926","volume":"144","author":"Moskophidis D.","year":"1990","journal-title":"J. Immunol."},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.4049\/jimmunol.138.7.2278","volume":"138","author":"Leist T. P.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1128\/jvi.62.6.2102-2106.1988","volume":"62","author":"Ahmed R.","year":"1988","journal-title":"J. Virol."},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.4049\/jimmunol.141.4.1150","volume":"141","author":"Banerjee S.","year":"1988","journal-title":"J. Immunol."},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199107000-00023"},{"key":"e_1_2_1_33_2","first-page":"121","volume":"76","author":"Volk H.\u2010D.","year":"1989","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.4049\/jimmunol.138.9.2771","volume":"138","author":"Kelley V. E.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8178155"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266076"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266077"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266078"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8128231"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90333-6"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/2.6.521"},{"key":"e_1_2_1_42_2","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.4049\/jimmunol.142.4.1287","volume":"142","author":"Kasaian M. T.","year":"1989","journal-title":"J. Immunol."},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.6.2159"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.18.8252"},{"key":"e_1_2_1_45_2","volume-title":"Fundamental Immunology","author":"Weiss A.","year":"1993"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/328077a0"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-68-3-825"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1989.tb02476.x"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.2.317"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830170213"},{"key":"e_1_2_1_51_2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4049\/jimmunol.142.1.270","volume":"142","author":"Mizuochi T.","year":"1989","journal-title":"J. Immunol."},{"key":"e_1_2_1_52_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4049\/jimmunol.144.1.299","volume":"144","author":"Kasaian M. T.","year":"1990","journal-title":"J. Immunol."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830241227","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830241227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T02:28:09Z","timestamp":1698114489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830241227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1994,12]]}},"alternative-id":["10.1002\/eji.1830241227"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830241227","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12]]}}}