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Starting at the age of 16 weeks NZB\/W F1 mice were treated for a period of 19 weeks with soluble interferon\u2010\u03b3 receptor (sIFN\u2010\u03b3R), anti\u2010IFN\u2010\u03b3 monoclonal antibody (mAb) or IFN\u2010\u03b3. All mice treated with sIFN\u2010\u03b3R or anti\u2010IFN\u2010\u03b3 mAb were alive 4 weeks after the treatment was discontinued, whereas 50% of mice died in the placebo groups and 78% of the mice died in the IFN\u2010\u03b3\u2010treated group. Histologically, there was severe membrano\u2010proliferative glomerulonephritis in IFN\u2010\u03b3\u2010 and placebo\u2010treated mice, and minimal or no mesangioproliferative disease in mice receiving sIFN\u2010\u03b3R or anti\u2010IFN\u2010\u03b3 mAb. The renal mononuclear infiltrate (T lymphocytes and monocytes), expression of major histocompatibility complex class II antigen and glomerular immunoglobulin and complement deposition were reduced in those mice. These data suggest that an IFN\u2010\u03b3 inhibitor, such as the soluble IFN\u2010\u03b3R, can be used for SLE therapy in the early stages of the disease.<\/jats:p>","DOI":"10.1002\/eji.1830250103","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T23:14:59Z","timestamp":1172790899000},"page":"6-12","source":"Crossref","is-referenced-by-count":137,"title":["Experimental therapy of systemic lupus erythematosus: the treatment of NZB\/W mice with mouse soluble interferon\u2010\u03b3 receptor inhibits the onset of glomerulonephritis"],"prefix":"10.1002","volume":"25","author":[{"given":"Laurence","family":"Ozmen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani\u00e8le","family":"Roman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fountoulakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Ryffel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Garotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60342-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.3.798"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.4049\/jimmunol.143.11.3470","volume":"143","author":"Brennan D. 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