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Cross\u2010linking of membrane IgM (mIgM) induced an increase in intracellular free Ca<jats:sup>2+<\/jats:sup> as a result of the release from intracellular stores and an influx of extracellular Ca<jats:sup>2+<\/jats:sup>. When the B cells were incubated with limiting concentrations of anti\u2010IgM, co\u2010ligation of mIgM and CD54, but not CD19, resulted in an inhibition of the Ca<jats:sup>2+<\/jats:sup> response. Separate cross\u2010linking of mIgM and CD54 under these conditions, using isotype mismatched monoclonal antibodies (mAb), did not affect the mobilization of Ca<jats:sup>2+<\/jats:sup>. The CD54\u2010mediated inhibition of the Ca<jats:sup>2+<\/jats:sup> response was also observed in the absence of extracellular Ca<jats:sup>2+<\/jats:sup>. All CD54 mAb tested (F10.2, F10.3 and F7.11) interfered with mIgM signaling. The results presented in this report imply that CD54 is linked to intracellular signaling pathways and, via co\u2010ligation with mIgM, interferes in the release of Ca<jats:sup>2+<\/jats:sup> from intracellular stores.<\/jats:p>","DOI":"10.1002\/eji.1830250126","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T23:14:59Z","timestamp":1172790899000},"page":"154-158","source":"Crossref","is-referenced-by-count":17,"title":["Co\u2010Iigation of ICAM\u20101 (CD54) and membrane IgM negatively affects B cell receptor signaling"],"prefix":"10.1002","volume":"25","author":[{"given":"Martin","family":"van Horssen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stoffer","family":"Loman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ger T.","family":"Rijkers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia E.","family":"Boom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andries C.","family":"Bloem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90434-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/331624a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.137.1.245"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1989.tb00016.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/346425a0"},{"key":"e_1_2_1_7_2","first-page":"121","volume":"135","author":"Munro J. 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