{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:25:16Z","timestamp":1770837916958,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":3973,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune gastritis, a CD4<jats:sup>+<\/jats:sup> T cell\u2010mediated organ\u2010specific autoimmune disease, can be induced by thymectomy of neonatal, but not of older, BALB\/c mice. Here we have shown that autoimmune gastritis can also be induced in 6\u20138\u2010week\u2010old BALB\/c mice by thymectomy combined with a single dose of cyclophosphamide (300 mg\/kg). This treatment reduced the numbers of splenic T and B cells approximately 25\u2010fold. However, by 8 days after treatment, the number of splenic lymphocytes had returned to normal adult levels. Approximately 50% of treated mice developed autoimmune gastritis after 10\u201312 weeks. These mice had mononuclear cellular infiltrates within the gastric mucosa and serum autoantibodies to the \u03b1 and \u03b2 subunits of the gastric H<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> ATPase. Transgenic mice, expressing the gastric H<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> ATPase \u03b2\u2010subunit in the thymus (Alderuccio, F., Toh, B. H., Tan, S. S., Gleeson, P. A. and van Driel, I. R., <jats:italic>J. Exp. Med.<\/jats:italic> 1993. <jats:italic>178:<\/jats:italic> 419), did not develop autoimmune gastritis after the adult thymectomy\/cyclophosphamide treatment. Thus a T cell response to the H<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> ATPase \u03b2\u2010subunit is likely to be required for the onset of gastritis. These observations suggest that pathogenic autoreactive T cells exist in the periphery of normal adult mice and that autoimmunity can be induced by the activation of these autoreactive T cells following transient lymphopenia. Cyclophosphamide\u2010treatment of adult mice without thymectomy did not induce autoimmune gastritis, suggesting thymic regulation of these pathogenic T cells.<\/jats:p>","DOI":"10.1002\/eji.1830250139","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T23:14:59Z","timestamp":1172790899000},"page":"238-244","source":"Crossref","is-referenced-by-count":63,"title":["Organ\u2010specific autoimmunity induced by adult thymectomy and cyclophosphamide\u2010induced lymphopenia"],"prefix":"10.1002","volume":"25","author":[{"given":"Simon P.","family":"Barrett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ban\u2010Hock","family":"Toh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Alderuccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian R.","family":"van Driel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Gleeson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00344296"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90413-1"},{"key":"e_1_2_1_4_2","first-page":"293","volume":"126","author":"Tung K. 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