{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:31:30Z","timestamp":1778682690285,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":3798,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Excessive T cell activation induced by bacterial superantigens plays an important role in the pathology associated with Gram\u2010positive bacteremia. To gain insight into the early phases of T cell activation by bacterial enterotoxins <jats:italic>in vivo<\/jats:italic>, we investigated the ability of antibodies to well\u2010defined co\u2010stimulatory molecules to inhibit T cell activation and the subsequent toxic shock syndrome induced in BALB\/c mice following the injection of staphylococcal enterotoxin B (SEB). We demonstrate here that a single dose of anti\u2010B7.2 antibodies, but not anti\u2010B7.1 antibodies, significantly inhibits T cell activation, as judged by lower systemic IL\u20102 release, blastogenesis and IL\u20102 receptor expression, and reduces the lethal effect of SEB in D\u2010galactosamine\u2010sensitized mice. These results demonstrate that co\u2010stimulation through the B7.2 molecule plays an important role in the activation of T cells in response to SEB <jats:italic>in vivo<\/jats:italic> and suggest alternative therapies for septic shock caused by bacterial enterotoxins based on blocking antibodies to co\u2010stimulatory molecules.<\/jats:p>","DOI":"10.1002\/eji.1830250747","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:47:23Z","timestamp":1172796443000},"page":"2111-2114","source":"Crossref","is-referenced-by-count":15,"title":["B7.2 provides co\u2010stimulatory functions <i>in vivo<\/i> in response to staphylococcal enterotoxin B"],"prefix":"10.1002","volume":"25","author":[{"given":"Eric","family":"Muraille","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibaut","family":"de Smedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Urbain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Moser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oberdan","family":"Leo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"100","volume":"54","author":"Kotzin B. 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