{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:05:59Z","timestamp":1789877159849,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":3798,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have shown previously both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> that IL\u20106 is an important factor for the development of IgA\u2010producing B cells. However, despite the lack of this cytokine in mice with targeted disruption of the interleukin (IL)\u20106 gene (gene knockout mice), a substantial number of IgA\u2010producing plasma cells occur in their intestinal mucosa. The experiments reported here indicate that there is a population of IgA\u2010producing B cell precursors originating from the peritoneal cavity, distinguished from conventional Peyer's patch\u2010derived precursors by their expression of CD5, and that IgA secretion by these cells is IL\u20106\u2010independent. Further, there is an increase in CD5 expression among brightly staining IgA\u2010producing cells obtained from the intestinal lamina propria of IL\u20106 gene\u2010disrupted mice compared to normal controls. These data suggest an explanation for the persistence of IgA\u2010producing plasma cells in the intestinal mucosa of IL\u20106\u2010depleted mice and indicate the importance of IL\u20106 for development of conventional precursors of IgA\u2010producing B cells, but not those derived from the peritoneal cavity pool.<\/jats:p>","DOI":"10.1002\/eji.1830250750","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:47:23Z","timestamp":1172796443000},"page":"2123-2126","source":"Crossref","is-referenced-by-count":27,"title":["IgA production by peritoneal cavity B cells is IL\u20106 independent: Implications for intestinal IgA response"],"prefix":"10.1002","volume":"25","author":[{"given":"Kenneth W.","family":"Beagley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shisan","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair J.","family":"Ramsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Eldridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Husband","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.134.1.188"},{"key":"e_1_2_1_3_2","first-page":"25","volume-title":"Progress in Veterinary Microbiology and Immunology","author":"Husband A. 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