{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:50:04Z","timestamp":1790898604182,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":3767,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1995,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although T helper cells play a critical role in human immunity against schistosomes, the properties of the T lymphocytes that govern resistance and pathogenesis in human schistosomiasis are still poorly defined. This work addresses the question as to whether human resistance to <jats:italic>Schistosoma mansoni<\/jats:italic> is associated with a particular T helper subset. Twenty\u2010eight CD3<jats:sup>+<\/jats:sup>, CD4<jats:sup>+<\/jats:sup>, CD8<jats:sup>\u2212<\/jats:sup> parasite\u2010specific T cell clones were isolated from three adults with high degree of resistance to infection by <jats:italic>S. mansoni<\/jats:italic>. The lymphokine secretion profiles of these clones were determined and compared to those of 21 CD3<jats:sup>+<\/jats:sup>, CD4<jats:sup>+<\/jats:sup>, CD8<jats:sup>\u2212<\/jats:sup> clones with unknown specificity, established from these same subjects in the same cloning experiment. Almost all parasite\u2010specific clones produced interleukin (IL)\u20104 and interferon (IFN)\u2010\u03b3 in large amounts. However, they generally produced more IL\u20104 than IFN\u2010\u03b3; variations in IL\u20104\/IFN\u2010\u03b3 ratios were accounted for by differences in IFN\u2010\u03b3 production since IL\u20104 levels were comparable for the clones from the three subjects. T cell clones of unknown specificity produced significantly less IL\u20104 and more IFN\u2010\u03b3 than parasite\u2010specific T cell clones. Most clones produced IL\u20102, and IL\u20102 production did not differ between the two types of clones. Parasite\u2010specific T cell clones from the resistant subjects were compared to specific T cell clones from a sensitized adult from a nonendemic area: T cell clones from this latter subject were the highest IFN\u2010\u03b3 and the lowest IL\u20104 producers, compared to those of resistant subjects. Thus, parasite\u2010specific T cell clones isolated from adults resistant to <jats:italic>S. mansoni<\/jats:italic> belong to the Th0 subset and produced more IL\u20104 than IFN\u2010\u03b3 (Th0\/2), whereas clones of a sensitized adult from a nonendemic area are also Th0, but produce more IFN\u2010\u03b3 than IL\u20104 (Th0\/1). These results support previous conclusions on the role of IgE in protection against schistosomes in humans, and may indicate that IFN\u2010\u03b3 is required for full protection.<\/jats:p>","DOI":"10.1002\/eji.1830250827","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:17:47Z","timestamp":1172798267000},"page":"2295-2302","source":"Crossref","is-referenced-by-count":53,"title":["<i>Schistosoma<\/i>\u2010specific helper T cell clones from subjects resistant to infection by <i>Schistosoma mansoni<\/i> are Th0\/2"],"prefix":"10.1002","volume":"25","author":[{"given":"Patricia","family":"Couissinier\u2010Paris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain J.","family":"Dessein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.7.2348"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.001303"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90137-I"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.4049\/jimmunol.144.12.4651","volume":"144","author":"Wierenga E. 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