{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T16:03:57Z","timestamp":1747584237649},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":3736,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The induction of apoptosis via surface IgM (sIgM) in immature B cells requires <jats:italic>de novo<\/jats:italic> transcription. To investigate the regulation of activation\u2010induced cell death (AICD) in B cells we used a cell line model consisting of an Epstein\u2010Barr virus\u2010negative Burkitt lymphoma cell line (BL41), which is highly sensitive, and a subclone which is resistant to sIgM\u2010mediated apoptosis (BL41\/B5). Resistance in this cell line was not due to down\u2010regulation of sIgM or functional impairment in signal transduction of the surface Ig complex. The zinc finger transcription factor nur77 has been implicated to play an important role in CD3\u2010mediated apoptosis in murine T cells. We were able to demonstrate that surface IgM ligation and subsequent apoptosis in BL41 cells is associated with a concomitant induction of NAK\u20101, the human nur77 homologue. Induction of NAK\u20101 mRNA and DNA binding activity in the nucleus could be readily observed by means of Northern blot and electrophoretic mobility shift assay, respectively. In contrast, the resistant clone BL41\/B5 did not show any NAK\u20101 expression upon stimulation. This suggests a role for NAK\u20101 in sIgM\u2010mediated apoptosis of immature B cells.<\/jats:p>","DOI":"10.1002\/eji.1830250915","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:17:30Z","timestamp":1172798250000},"page":"2506-2510","source":"Crossref","is-referenced-by-count":13,"title":["Involvement of NAK\u20101, the human nur77 homologue, in surface IgM\u2010mediated apoptosis in Burkitt lymphoma cell line BL41"],"prefix":"10.1002","volume":"25","author":[{"given":"Markus Y.","family":"Mapara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Weinmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Bommert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter T.","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Bargou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"D\u00f6rken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)62312-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00048057"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(94)90102-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90032-T"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90111-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830200810"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/342929a0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830210819"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90214-6"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1995.2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830231115"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/j.1460-2075.1993.tb05799.x","volume":"12","author":"Cuende E.","year":"1993","journal-title":"EMBO J."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250426"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250322"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.11.8.4177"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05481.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/367281a0"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/367277a0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend-4-10-1438"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/nar\/11.5.1475","volume":"11","author":"Dignam J. 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