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Densitometric patterns of reactivity of purified IgG with self antigens were highly conserved between individuals within a given age group and across age groups. Inter\u2010individual differences were observed, however, upon analysis of self reactivities of IgG in whole serum. A striking heterogeneity between individuals within a given age group and across age groups characterized the reactivity of purified IgG and of IgG in whole serum with bacterial antigens. Inter\u2010individual differences were more marked among aged individuals than among individuals of other age groups. Analysis of variances of reactivities of IgG with bacterial antigens further demonstrated an increased diversity of repertoires of aged donors compared with those of young adults and children. Our results document the stability of the self\u2010reactive repertoires of IgG throughout life, which contrasts with the diversification of the repertoire of IgG antibody reactivities directed toward foreign antigens with aging. These findings support the concept that self\u2010reactive antibody repertoires are positively selected throughout life by a restricted set of self antigens shared by all individuals.<\/jats:p>","DOI":"10.1002\/eji.1830250929","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:17:30Z","timestamp":1172798250000},"page":"2598-2604","source":"Crossref","is-referenced-by-count":97,"title":["Analysis of the natural human IgG antibody repertoire: life\u2010long stability of reactivities towards self antigens contrasts with age\u2010dependent diversification of reactivities against bacterial antigens"],"prefix":"10.1002","volume":"25","author":[{"given":"S\u00e9bastien","family":"Lacroix\u2010Desmazes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Mouthon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel D.","family":"Kazatchkine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0769-2625(81)90031-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.4049\/jimmunol.128.6.2779","volume":"128","author":"Guilbert B.","year":"1982","journal-title":"J. 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