{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:50:55Z","timestamp":1770756655734,"version":"3.50.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":3736,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune gastritis, induced by day\u20103 thymectomy of BALB\/c mice, is a destructive CD4<jats:sup>+<\/jats:sup>T cell\u2010mediated disease characterized by leukocyte infiltrates in the gastric mucosa, loss of parietal and chief cells and anti\u2010gastric H\/K ATPase autoantibodies. Our previous studies have indicated that a T cell response to the H\/K ATPase \u03b2 subunit is required for the onset of autoimmune gastritis (Alderuccio, F., Toh, B. H., Tan, S. S., Gleeson, P. A. and van Driel, I. R.,<jats:italic>J. Exp. Med.<\/jats:italic>1993.<jats:italic>178:<\/jats:italic>419). To determine whether a response to the \u03b2 subunit autoantigen is alone sufficient to induce autoimmunity, or whether other tissue\u2010specific factors are required, we have generated transgenic mice expressing the gastric H\/K ATPase \u03b2 subunit in \u03b2 islet cells of the pancreas (RIP\u2010H\/K\u03b2). RIP\u2010H\/K\u03b2 mice developed autoimmune gastritis and insulitis after day\u20103 thymectomy. Significantly, insulitis, observed as a peri\u2010islet infiltrate, was only detected in thymectomized mice with autoimmune gastritis. There was no apparent immune destruction of the pancreas as insulitis did not progress to invasion of the islets or diabetes. Double transgenic mice, expressing the gastric H\/K ATPase \u03b2 subunit in the thymus and in the pancreas, were protected from both gastritis and insulitis after day\u20103 thymectomy. Therefore, insulitis in the RIP\u2010H\/K\u03b2 mice appears to be dependent on a T cell response to the H\/K ATPase \u03b2 subunit. This is the first example where an organ\u2010specific initiating autoantigen has been expressed in another peripheral tissue. Autoimmune destruction in the stomach, but not the pancreas, indicates that tissue\u2010specific factors play a fundamental role in the development of organ\u2010specific autoimmunity.<\/jats:p>","DOI":"10.1002\/eji.1830250943","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:17:30Z","timestamp":1172798250000},"page":"2686-2694","source":"Crossref","is-referenced-by-count":13,"title":["Expression of a gastric autoantigen in pancreatic islets results in non\u2010destructive insulitis after neonatal thymectomy"],"prefix":"10.1002","volume":"25","author":[{"given":"Simon P.","family":"Barrett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian R.","family":"Van Driel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010Seng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Alderuccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ban\u2010Hock","family":"Toh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Gleeson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00344296"},{"key":"e_1_2_1_3_2","first-page":"293","volume":"126","author":"Tung K. S.","year":"1987","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90413-1"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.16.6418"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90036-S"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90002-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb06878.x"},{"key":"e_1_2_1_9_2","first-page":"207","volume-title":"The Handbook of Physiology \u2013 The Gastrointestinal System III","author":"Forte J. G.","year":"1989"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.52.030190.001541"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.161.1.72"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.4049\/jimmunol.149.6.2212","volume":"149","author":"Smith H.","year":"1992","journal-title":"J. Immunol."},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250139"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.4049\/jimmunol.147.9.2928","volume":"147","author":"Smith H.","year":"1991","journal-title":"J. Immunol."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.419"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)48410-4"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90391-1"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90521-F"},{"key":"e_1_2_1_19_2","volume-title":"Manipulation of the mouse embryo","author":"Hogan B.","year":"1986"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(91)90443-7"},{"key":"e_1_2_1_21_2","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook J.","year":"1989"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/oso\/9780199631964.003.0013","volume-title":"PCR: A Practical Approach","author":"Dallman M. J.","year":"1991"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/359547a0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6707"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90497-7"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/339622a0"},{"key":"e_1_2_1_27_2","first-page":"423","volume":"36","author":"Zafirova M.","year":"1992","journal-title":"Eur. J. Histochem."},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/333529a0"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.06.110190.002425"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.10.040192.000411"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90317-E"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/325223a0"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90164-T"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90165-U"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90011-6"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(93)90063-X"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(92)90050-O"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.4.869"},{"key":"e_1_2_1_39_2","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.4049\/jimmunol.146.9.3074","volume":"146","author":"Wolf S. F.","year":"1991","journal-title":"J. Immunol."},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90189-9"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091620109"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00262208"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-198910000-00011"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092360205"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90730-E"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830250943","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830250943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T09:59:25Z","timestamp":1707645565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830250943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1002\/eji.1830250943"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830250943","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}