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In contrast, a nonapeptide related to a tumor rejection antigen, P815AB, failed in this study to elicit DTH after sensitization of mice with irradiated tumor cells or adoptive transfer of P815AB\u2010pulsed dendritic cells. Unresponsiveness, however, could be overcome by immunization with tumor cells co\u2010expressing P815AB and tum<jats:sup>\u2212<\/jats:sup> antigens. When used for cell pulsing <jats:italic>in vitro<\/jats:italic>, a mixture of P815AB and tum<jats:sup>\u2212<\/jats:sup> peptides was also highly effective in inducing anti\u2010P815AB reactivity, as was the combined use of P815AB and class II\u2010restricted peptides of tetanus toxin or <jats:italic>Plasmodium berghei<\/jats:italic> circumsporozoite protein. While the effector phase of the CD8<jats:sup>+<\/jats:sup> cell\u2010mediated DTH to P815AB was unaffected by the ablation of CD4<jats:sup>+<\/jats:sup> cells, the same treatment, or neutralization of IFN\u2010\u03b3, negated the induction of reactivity if it occurred at the time of sensitization. Thus, defective activation of CD4<jats:sup>+<\/jats:sup> cells may contribute to the poor immunogenicity of P815AB. Besides providing an insight into the mechanisms of anti\u2010tumor protection induced by tum<jats:sup>\u2212<\/jats:sup> cells, these data offer useful information for the design of vaccination strategies against identified tumor antigens.<\/jats:p>","DOI":"10.1002\/eji.1830251013","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T23:39:23Z","timestamp":1172792363000},"page":"2797-2802","source":"Crossref","is-referenced-by-count":16,"title":["CD8<sup>+<\/sup> cell activation to a major mastocytoma rejection antigen, P815AB: requirement for tum<sup>\u2212<\/sup> or helper peptides in priming for skin test reactivity to a P815AB\u2010related peptide"],"prefix":"10.1002","volume":"25","author":[{"given":"Ursula","family":"Grohmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Fioretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Fallarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Binaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Uyttenhove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"van Pel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Boon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Puccetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90051-L"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(93)90124-B"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3539"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.3.897"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.150.5.1134"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.3.768"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.4049\/jimmunol.151.12.6742","volume":"151","author":"Levin D.","year":"1993","journal-title":"J. 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