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In this report, we show that following incubation of L540 cells (Hodgkin's disease\u2010derived, T cell\u2010like, CD30<jats:sup>+<\/jats:sup> cells) with the agonistic anti\u2010CD30 monoclonal antibodies (mAb) M44 and M67, two nuclear factor (NF)\u2010\u03f0B DNA binding activities were induced in nuclear extracts, as determined in gel retardation assays. The effect of the mAb towards NF\u2010\u03f0B activation was rapid, as it occurred within 20 min, and was sustained for up to 6h. By comparison, an isotype\u2010matched antibody had no effect on NF\u2010\u03f0B activation. Moreover, in human T helper (Th) clones functionally characterized as being of the type 0, type 1 and type 2 (28%, &lt; 1% und 93% CD30<jats:sup>+<\/jats:sup>, respectively), the extent of CD30\u2010mediated NF\u2010\u03f0B activation correlated with the proportion of CD30<jats:sup>+<\/jats:sup> cells. In all cell lines investigated, the NF\u2010\u03f0B complexes induced following CD30 engagement were shown to contain p50 NF\u2010\u03f0B1, p65 RelA, and possibly other transcription factors. Collectively, our results demonstrate that nuclear translocation and activation of NF\u2010\u03f0B rank among the short\u2010term cellular responses elicited following CD30 ligation.<\/jats:p>","DOI":"10.1002\/eji.1830251024","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T23:39:23Z","timestamp":1172792363000},"page":"2870-2876","source":"Crossref","is-referenced-by-count":47,"title":["CD30 ligation induces nuclear factor\u2010\u03f0B activation in human T cell lines"],"prefix":"10.1002","volume":"25","author":[{"given":"Patrick P.","family":"McDonald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Cassatella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Bald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Romagnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010J\u00fcrgen","family":"Gruss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pizzolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/299065a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1182\/blood.V66.4.848.848","volume":"66","author":"Stein H.","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1182\/blood.V63.6.1299.1299","volume":"63","author":"Andreesen R.","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.4049\/jimmunol.151.5.2380","volume":"151","author":"Ellis T. 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