{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:46:58Z","timestamp":1759333618692},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":3706,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Superantigens bind to major histocompatibility complex (MHC) class II proteins and interact with variable parts of the T cell antigen receptor (TCR) \u03b2\u2010chain. Cross\u2010linking the TCR with MHC class II molecules on the antigen\u2010presenting cell by the superantigen leads to T cell activation that plays an essential role in pathogenesis. Recent crystallographic data have resolved the structure of the complexes between HLA\u2010DR1 and staphylococcal enterotoxin B (SEB) and toxic shock syndrome toxin\u20101 (TSST\u20101), respectively. For TSST\u20101, these studies have revealed possible contact sites between the superantigen and the HLA\u2010DR1\u2010bound peptide. Here, we show that TSST\u20101 binding is dependent on the MHC\u2010II\u2010associated peptides by employing variants of T2 mutant cells deficient in loading of peptides to MHC class II molecules as superantigen\u2010presenting cells. On HLA\u2010DR3\u2010transfected T2 cells, presentation of TSST\u20101, but not SEB, was dependent on HLA\u2010DR3\u2010associated peptides. Thus, although these superantigens can be recognized in the context of multiple MHC class II alleles and isotypes, they clearly bind to specific subsets of MHC molecules displaying appropriate peptides.<\/jats:p>","DOI":"10.1002\/eji.1830251028","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T23:39:23Z","timestamp":1172792363000},"page":"2894-2898","source":"Crossref","is-referenced-by-count":32,"title":["Major histocompatibility complex class II\u2010associated peptides determine the binding of the superantigen toxic shock syndrome toxin\u20101"],"prefix":"10.1002","volume":"25","author":[{"given":"Arne","family":"von Bonin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svenja","family":"Ehrlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Malcherek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Fleischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1993.tb01531.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000319126"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60821-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90980-X"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90164-G"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1989.tb00003.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90130-7"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90388-U"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.22.9954"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997880"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/368711a0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997881"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00375376"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.4049\/jimmunol.148.8.2586","volume":"148","author":"Riberdy J. M.","year":"1992","journal-title":"J. Immunol."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1465617"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/360474a0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/368551a0"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/368554a0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90049-3"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.6.1405"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1128\/iai.58.9.3020-3028.1990","volume":"58","author":"Blanco L.","year":"1990","journal-title":"Infect. Immun."},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1695760"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.156.1.104"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830221043"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/5.10.1229"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.4049\/jimmunol.153.3.1141","volume":"153","author":"Malcherek G.","year":"1994","journal-title":"J. Immunol."},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/375148a0"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.4049\/jimmunol.147.11.3876","volume":"147","author":"Chintagumpala M. M.","year":"1991","journal-title":"J. Immunol."},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.4049\/jimmunol.143.8.2583","volume":"143","author":"Scholl P. R.","year":"1989","journal-title":"J. Immunol."},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.12.5507"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830251028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830251028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T19:45:26Z","timestamp":1698263126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830251028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["10.1002\/eji.1830251028"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830251028","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}