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Thus, the combination of IL\u20104 and anti\u2010CD40 monoclonal antibody (mAb) has been shown to stimulate IgE production <jats:italic>in vitro<\/jats:italic> by highly purified B cells. In this T cell\u2010independent system, strong homotypic aggregation of B cells is observed prior to the production of IgE. Flow cytometric analysis and cell binding assays showed that the stimulation of purified B cells with anti\u2010CD40 mAb plus IL\u20104 resulted in a striking increase of intercellular adhesion molecule (ICAM)\u20101(CD54) expression, an induction of CD43 and an avidity change of lymphocyte functional antigen (LFA)\u20101(CD11a\/CD18), with little augmentation of CD 18 expression. Addition of anti\u2010ICAM\u20101 mAb caused an inhibition of homotypic aggregation but augmented IgE synthesis by B cells stimulated with anti\u2010CD40 mAb and IL\u20104, although it did not affect B cell proliferation or IL\u20106 production by the B cells. Among the mAb against counter\u2010receptors for ICAM\u20101 tested, anti\u2010CD11a mAb suppressed IgE synthesis, while anti\u2010CD18 mAb and anti\u2010CD43 mAb had little effect. The enhancing or inhibitory effect of anti\u2010ICAM\u20101 mAb or anti\u2010CD11a mAb on IgE production was achieved by the increased or decreased expression of germline C\u03b5e transcripts by B cells stimulated with anti\u2010CD40 mAb and IL\u20104. These results indicate that B cell\u2010B cell interaction through ICAM\u20101 and one of its counter receptors, LFA\u20101, regulates IgE synthesis by modulating C\u03b5e germ\u2010line transcription.<\/jats:p>","DOI":"10.1002\/eji.1830260130","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:16:14Z","timestamp":1172798174000},"page":"192-200","source":"Crossref","is-referenced-by-count":21,"title":["B cell\u2010B cell interaction through intercellular adhesion molecule\u20101 and lymphocyte functional antigen\u20101 regulates immunoglobulin E synthesis by B cells stimulated with interleukin\u20104 and anti\u2010CD40 antibody"],"prefix":"10.1002","volume":"26","author":[{"given":"Yoshinori","family":"Katada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Aitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kikutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Suemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamitsu","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1096\/fasebj.6.14.1385241","volume":"6","author":"Purkerson J.","year":"1992","journal-title":"FASEB J."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/367425a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.05.040187.002241"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.4049\/jimmunol.136.12.4538","volume":"136","author":"Coffman R. 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