{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:12:43Z","timestamp":1770700363615,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":3622,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The patients included in this study belong to a subset of common variabie immunodeficiency (CVID) patients whose peripheral blood T cells have a T cell receptor (TCR)\u2010mediated activation defect leading to impaired expression of the interleukin (IL)\u20102 gene upon stimulation with recall antigens (tetanus toxoid, <jats:italic>Escherichia coli<\/jats:italic>) or superantigens (staphylococcal enterotoxins). In the present report we demonstrate that the patients' peripheral blood T cells failed to generate the second messenger inositol 1,4,5\u2010trisphosphate (Ins(1,4,5)P<jats:sub>3<\/jats:sub>) following stimulation with superantigen or mAb specific for the monomorphic region of the TCR \u03b2\u2010chain. Patients' T cell lines were also impaired in generating Ins(1,4,5)P<jats:sub>3<\/jats:sub> when stimulated with tetanus toxoid\u2010pulsed autologous monocytes. Addition of a second or third co\u2010stimulatory signal provided by recombinant IL\u20102, CD28 or both had no effect on the Ins(1,4,5)P<jats:sub>3<\/jats:sub> formation of the patients' antigen\u2010driven T cell lines. The T cell activation defect, however, was not absolute, as Ins(1,4,5)P<jats:sub>3<\/jats:sub> formation in the patients' T cells after phytohemagglutinin or aluminium fluoride stimulation was normal. The impairment in signal transduction via the T cell antigen receptor was limited to the patients' T cells, as no activation defect after ligation of surface immunoglobulin, the antigen receptor on B cells, could be detected.<\/jats:p>","DOI":"10.1002\/eji.1830260136","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:16:14Z","timestamp":1172798174000},"page":"231-237","source":"Crossref","is-referenced-by-count":30,"title":["Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency"],"prefix":"10.1002","volume":"26","author":[{"given":"Michael B.","family":"Fischer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann M.","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Hauber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Eggenbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vojtech","family":"Thon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Sasgary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha M.","family":"Eibl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb06228.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb02281.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90178-I"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1182\/blood.V84.12.4234.bloodjournal84124234","volume":"84","author":"Fischer M. 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